Major health impact of accelerated aging in young HIV-infected individuals on antiretroviral therapy
| Autor: | Erica Chai Yong Lee, Siti Azdiah Abdul Aziz, Megan McStea, Pauline Siew Mei Lai, Nor Syuhada Ahmad Bashah, Sasheela Ponampalavanar, Shahrul Bahyah Kamaruzzaman, Adeeba Kamarulzaman, Sharifah Faridah Syed Omar, Reena Rajasuriar, Pui Li Wong, Suzanne M. Crowe, Meng Li Chong, Sharon R Lewin, Iskandar Azwa |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Gerontology Adult Male medicine.medical_specialty Immunology Health impact Ethnic group MEDLINE HIV Infections 03 medical and health sciences 0302 clinical medicine Quality of life Interquartile range Internal medicine Surveys and Questionnaires medicine Immunology and Allergy Outpatient clinic Humans 030212 general & internal medicine Academic Medical Centers business.industry Malaysia Aging Premature Middle Aged 030112 virology Antiretroviral therapy Infectious Diseases Anti-Retroviral Agents Cohort Female business |
| Zdroj: | AIDS (London, England). 31(10) |
| ISSN: | 1473-5571 |
| Popis: | Background: Aging among HIV-infected individuals on antiretroviral therapy (ART) is a significant clinical challenge; however, studies assessing multidimensional aspects of aging are lacking. We characterized 10 geriatric conditions encompassing multiple functional domains, its health impact and associated risk factors in HIV-infected and age-matched uninfected controls. Methods: HIV-infected individuals were recruited from the outpatient clinic in University Malaya Medical Centre, Malaysia and controls from the community. All participants were aged at least 25 years of age with no acute illness, and HIV-infected individuals were on stable ART. Geriatric conditions were assessed and the burden scored as a composite of geriatric conditions present in an individual (total score = 10). Multivariate regression analysis was performed to determine the risk factors and health impact associated with the burden of geriatric conditions. Results: We analyzed data from 336 HIV-infected individuals (total HIV+), of whom 172 were matched for age, sex, and ethnicity with 172 HIV-uninfected controls (matched subset). In the total HIV-positive cohort, median (interquartile range) age was 44 (38-51) years and CD4 T-cell count was 562 (398-737) cells/μl. The burden of geriatric conditions was significantly higher in the HIV-infected group compared with controls (P < 0.001). With an increasing geriatric condition burden, quality-of-life scores were 2.2-times poorer, healthcare use five times greater, and mortality risk scores four times higher in the HIV-infected group compared with matched controls. Both sociobehavioural and HIV-related clinical factors were independently associated with an increasing burden of geriatric condition in HIV. Conclusions:A high burden of geriatric conditions with significant impact on health outcomes, including mortality risk scores are observed among HIV-infected individuals on ART in a resource-limited setting. |
| Databáze: | OpenAIRE |
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