Regeneration of articular cartilage in healer and non-healer mice
| Autor: | Linda J. Sandell, Muhammad Farooq Rai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cartilage
Articular Pathology medicine.medical_specialty Classical example LGXSM intercross Articular cartilage Osteoarthritis LG/J Regenerative medicine Article 03 medical and health sciences Mice 0302 clinical medicine medicine Animals Humans Regeneration Tissue repair Molecular Biology 030304 developmental biology 0303 health sciences Wound Healing Mouse strain business.industry Regeneration (biology) Articular cartilage regeneration medicine.disease 3. Good health Super-healer mice Disease Models Animal MRL/MpJ Immunology Wound healing business 030217 neurology & neurosurgery |
| Zdroj: | Matrix biology : journal of the International Society for Matrix Biology |
| ISSN: | 1569-1802 0945-053X |
| Popis: | Mammals rarely regenerate their lost or injured tissues into adulthood. MRL/MpJ mouse strain initially identified to heal full-thickness ear wounds now represents a classical example of mammalian wound regeneration since it can heal a spectrum of injuries such as skin and cardiac wounds, nerve injuries and knee articular cartilage lesions. In addition to MRL/MpJ, a few other mouse strains such as LG/J (a parent of MRL/MpJ) and LGXSM-6 (arising from an intercross between LG/J and SM/J mouse strains) have now been recognized to possess regenerative/healing abilities for articular cartilage and ear wound injuries that are similar, if not superior, to MRL/MpJ mice. While some mechanisms underlying regenerative potential have been begun to emerge, a complete set of biological processes and pathways still needs to be elucidated. Using a panel of healer and non-healer mouse strains, our recent work has provided some insights into the genes that could potentially be associated with healing potential. Future mechanistic studies can help seek the Holy Grail of regenerative medicine. This review highlights the regenerative capacity of selected mouse strains for articular cartilage, in particular, and lessons from other body tissues, in general. |
| Databáze: | OpenAIRE |
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