Radiation therapy and 5-fluorouracil modulated by leucovorin for adenocarcinoma of the pancreas. A phase I study
| Autor: | David J. Schifeling, Ralph R. Dobelhower, Andre Konski, John M. Howard, Hollis W. Merrick, Roland T. Skeel |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatic disease Nausea medicine.medical_treatment Leucovorin Adenocarcinoma Gastroenterology Endocrinology Internal medicine medicine Combined Modality Therapy Humans Antigens Tumor-Associated Carbohydrate Aged Chemotherapy Leukopenia business.industry Remission Induction Middle Aged medicine.disease Survival Analysis Surgery Radiation therapy Pancreatic Neoplasms Treatment Outcome Oncology Fluorouracil Vomiting Female medicine.symptom business medicine.drug |
| Zdroj: | International journal of pancreatology : official journal of the International Association of Pancreatology. 12(3) |
| ISSN: | 0169-4197 |
| Popis: | This Phase I study was designed to build on the Gastrointestinal Tumor Study Group’s experience with combined modality therapy in patients with pancreatic cancer. Thirteen patients with adenocarcinoma of the pancreas received weekly 5-fluorouracil by rapid intravenous infusion midway through a 2-h infusion of high dose leucovorin during external beam radiation therapy. Twelve patients received 100% of planned external beam radiation; treatment delays occurred in only three. Four patients received 100% of planned chemotherapy doses. Leukopenia and thrombocytopenia caused reduction of the number of chemotherapy doses given during radiation in six patients; diarrhea, severe nausea and vomiting, and wound abscess caused reduction in three patients. Ten patients were evaluable for response; two had complete responses, one had a partial response, and two had minor responses. In this small series baseline and post-treatment CA 19-9 levels predicted and correlated with response. We conclude that radiation and 5-FU modulated by leucovorin is a tolerable treatment regimen for carcinoma of the pancreas, with preliminary suggestion of activity, that warrants further Phase II testing. |
| Databáze: | OpenAIRE |
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