MicroRNA 21 and microRNA 155 levels in resistant hypertension, and their relationships with aldosterone

Autor:	Ahsen Yilmaz, Sonat Pınar Kara, Elif Geyik, Savas Guzel, Gulsum Ozkan, Nergiz Bayrakçı
Rok vydání:	2021
Předmět:	Male systolic blood pressure blood pressure measurement 030232 urology & nephrology Resistant hypertension 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Pathogenesis chemistry.chemical_compound 0302 clinical medicine Transcription (biology) middle aged Gene expression Medicine genetics RNA blood level Aldosterone pathophysiology clinical article microRNA resistant hypertension General Medicine Blood Pressure Monitoring Ambulatory Middle Aged Cell biology female hypertensive patient priority journal Nephrology Female Research Article Adult hypertension mirna 155 miRNA 21 microRNA 21 aldosterone blood level Article 03 medical and health sciences blood Humans controlled study human miRNA 155 Aged business.industry essential hypertension RNA case control study human tissue Diseases of the genitourinary system. Urology blood pressure monitoring MIRN21 microRNA human MicroRNAs chemistry Case-Control Studies gene expression Clinical Study microRNA 155 RC870-923 business mirna 21 MIRN155 microRNA human
Zdroj:	Renal Failure, Vol 43, Iss 1, Pp 676-683 (2021) Renal Failure article-version (VoR) Version of Record
ISSN:	1525-6049 0886-022X
DOI:	10.1080/0886022x.2021.1915800
Popis:	Aim: MicroRNAs (miRNAs) are non-coding RNA molecules that serve as regulators following gene expression transcription. While studies have investigated the role of miRNAs in the pathogenesis of essential hypertension (HT), very few have considered their place in the pathogenesis of resistant hypertension (RH). The purpose of this study was to investigate levels of miRNA 21 and miRNA 155 in RH and their relationships with aldosterone. Method: Thirty-two normotensive patients, 30 newly diagnosed HT patients, and 20 RH patients were included in the study. Patients’ demographic data were recorded, and office blood pressure measurement and 24-h ambulatory blood pressure monitoring (24-h ABPM) were performed. Blood specimens were collected for miRNA 21, miRNA 155 and aldosterone measurement. MiRNA 21 and miRNA 155 levels in the control and patient groups and their relations with other demographic and biochemical parameters were then subjected to analysis. Results: No difference was determined in miRNA 155 levels between the groups, but miRNA 21 and aldosterone levels were significantly higher in the RH group (p < 0.001 and
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a7967c9fbbcf41947e3a1ad52130f6 https://doi.org/10.1080/0886022x.2021.1915800 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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