Precise inhibitory microcircuit assembly of developmentally related neocortical interneurons in clusters
| Autor: | Zhi Han, Zhizhong Li, Xin-Jun Zhang, Kun Huang, Song-Hai Shi, Khadeejah T. Sultan |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Ganglionic eminence Interneuron genetic structures Chemical synapse Science General Physics and Astronomy Neocortex Biology Inhibitory postsynaptic potential General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Electrical Synapses Interneurons medicine Animals Cell Lineage Multidisciplinary musculoskeletal neural and ocular physiology General Chemistry Preoptic area Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure nervous system Excitatory postsynaptic potential Female Neuroscience |
| Zdroj: | Nature Communications Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
| ISSN: | 2041-1723 |
| Popis: | GABA-ergic interneurons provide diverse inhibitions that are essential for the operation of neuronal circuits in the neocortex. However, the mechanisms that control the functional organization of neocortical interneurons remain largely unknown. Here we show that developmental origins influence fine-scale synapse formation and microcircuit assembly of neocortical interneurons. Spatially clustered neocortical interneurons originating from low-titre retrovirus-infected radial glial progenitors in the embryonic medial ganglionic eminence and preoptic area preferentially develop electrical, but not chemical, synapses with each other. This lineage-related electrical coupling forms predominantly between the same interneuron subtype over an extended postnatal period and across a range of distances, and promotes action potential generation and synchronous firing. Interestingly, this selective electrical coupling relates to a coordinated inhibitory chemical synapse formation between sparsely labelled interneurons in clusters and the same nearby excitatory neurons. These results suggest a link between the lineage relationship of neocortical interneurons and their precise functional organization. Developmental neuroscientists have long asked if clonally-related neurons retain functional relationships after maturation. The authors show that sparsely labelled neocortical interneurons in clusters with high possibility of clonal relation preferentially form electrical, but not chemical, synapses. |
| Databáze: | OpenAIRE |
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