SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-week interval between doses
| Autor: | Debashree Chatterjee, Alexandra Tauzin, Lorie Marchitto, Shang Yu Gong, Marianne Boutin, Catherine Bourassa, Guillaume Beaudoin-Bussières, Yuxia Bo, Shilei Ding, Annemarie Laumaea, Dani Vézina, Josée Perreault, Laurie Gokool, Chantal Morrisseau, Pascale Arlotto, Éric Fournier, Aurélie Guilbault, Benjamin Delisle, Inès Levade, Guillaume Goyette, Gabrielle Gendron-Lepage, Halima Medjahed, Gaston De Serres, Cécile Tremblay, Valérie Martel-Laferrière, Daniel E. Kaufmann, Renée Bazin, Jérémie Prévost, Sandrine Moreira, Jonathan Richard, Marceline Côté, Andrés Finzi |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Vaccines Synthetic Time Factors SARS-CoV-2 Vaccination Immunization Secondary Quebec Middle Aged Antibodies Viral Antibodies Neutralizing General Biochemistry Genetics and Molecular Biology Cohort Studies Young Adult HEK293 Cells Spike Glycoprotein Coronavirus Humans Female mRNA Vaccines Vaccine Potency BNT162 Vaccine Immunization Schedule Aged |
| Zdroj: | Cell reports. 38(9) |
| ISSN: | 2211-1247 |
| Popis: | SUMMARYContinuous emergence of SARS-CoV-2 variants of concern (VOC) is fueling the COVID-19 pandemic. Omicron (B.1.1.529), is rapidly spreading worldwide. The large number of mutations in its Spike raised concerns about a major antigenic drift that could significantly decrease vaccine efficacy and infection-induced immunity. A long interval between BNT162b2 mRNA doses was shown to elicit antibodies that efficiently recognize Spikes from different VOCs. Here we evaluated the recognition of Omicron Spike by plasma from a cohort of SARS-CoV-2 naïve and previously-infected individuals that received their BNT162b2 mRNA vaccine 16-weeks apart. Omicron Spike was recognized less efficiently than D614G, Alpha, Beta, Gamma and Delta Spikes. We compared to plasma activity from participants receiving a short (4-weeks) interval regimen. Plasma from individuals of the long interval cohort recognized and neutralized better the Omicron Spike compared to those that received a short interval. Whether this difference confers any clinical benefit against Omicron remains unknown. |
| Databáze: | OpenAIRE |
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