Comparative bactericidal activities of beta-lactam antibiotics determined in agar and broth media
Autor: | Kishio Nakamura, Tokuo Yanagishita, Gohta Masuda, Taro Yajima, Harukuni Hayashi |
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Rok vydání: | 1979 |
Předmět: |
Klebsiella
food.ingredient medicine.drug_class Antibiotics Microbial Sensitivity Tests medicine.disease_cause beta-Lactams Benzylpenicillin beta-Lactamases Microbiology food Drug Discovery polycyclic compounds medicine Agar Escherichia coli Pharmacology biology Bacteria Pseudomonas aeruginosa biochemical phenomena metabolism and nutrition Carbenicillin biology.organism_classification Anti-Bacterial Agents Culture Media medicine.drug |
Zdroj: | The Journal of antibiotics. 32(11) |
ISSN: | 0021-8820 |
Popis: | Comparative bactericidal activities were determined utilizing a relatively large number of test strains, in both agar and broth media, with special reference to the time of exposure of the bacteria to certain beta-lactam antibiotics. It was apparent that the activities increase with time. The concentrations producing a 99.9% kill with cephalothin for Escherichia coli, Klebsiella sp., and carbenicillin for Pseudomonas aeruginosa were higher in broth than in agar. In contrast, those of benzylpenicillin for alpha-streptococcus (non-enterococcal) were higher in agar than in broth. If the bactericidal concentrations with 3-hour or 6-hour exposure to antibiotics were used as the criterion, these concentrations of carbenicillin for P. aeruginosa, and benzylpenicillin for alpha-streptococcus were, in particular, unusually high compared with the conventionally determined bacteriostatic concentrations (MICs). |
Databáze: | OpenAIRE |
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