The protocol for the Prospective Urban Rural Epidemiology China Action on Spine and Hip status study
| Autor: | Ya-Hong Zhi, Yizhong Chen, Zhi-Wei Shi, Li He, Shaoqi Xu, Xiaoguang Cheng, Ren-Sheng Lei, Lu Yin, Yonghong Jiang, Yuan-Zheng Ma, Ling Wang, Yangyang Duanmu, Wei Tian, Zhi-Jian Chen, Gang Ning, Lei Zhu, Yu Liu, Xiao Chen, Fengzhe Wang, Liang Wang, Jian Bo, Shiwei Liu, Jiman Shao, Wen-Hua Zhao, Xiaolin Zhang, Lin-Fen Zhao, Baoqing Li, Jun Zhou, Jun-Ying Wang, Yong Zhang, Quanyong Xiang, Kai Li, Hui Chen, Wei Li, Qian Zhao, Yang Wang, Xiaoguang Hao |
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| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Bone mineral medicine.medical_specialty education.field_of_study medicine.diagnostic_test business.industry Osteoporosis Population 030209 endocrinology & metabolism medicine.disease 03 medical and health sciences 0302 clinical medicine Informed consent Research Highlights Spinal fracture Epidemiology medicine Physical therapy Population study Radiology Nuclear Medicine and imaging 030101 anatomy & morphology Quantitative computed tomography education business |
| Zdroj: | Quantitative Imaging in Medicine and Surgery. 8:667-672 |
| ISSN: | 2223-4306 2223-4292 |
| DOI: | 10.21037/qims.2018.08.07 |
| Popis: | The Prospective Urban Rural Epidemiology (PURE) China Action on Spine and Hip status (CASH) study focused on the prevalence of osteoporosis and spinal fracture in China. The aim of the PURE CASH study is to determine the prevalence of osteoporosis and spinal fracture, and explore the potential relationship between spinal fracture and bone mineral density (BMD). This study is a prospective large-scale population study with a community-based sampling and recruitment strategy. The aim is to determine the prevalence of osteoporosis and vertebral fracture in this population, to evaluate the association between vertebral fractures and BMD values, and to assess the prediction power of BMD for incident fractures. Participants in the PURE CASH study are all from the PURE study in China, recruited from 12 centers in 7 Chinese provinces. The inclusion criteria are that participants should be aged more than 40 years and able to give informed consent. Exclusion criteria are pregnant women, individuals with metal implants in the lumbar spine, use of medications or the existence of any disease or condition known to have a major influence on BMD, and inability to give informed consent. A total of 3,457 participants undergo a quantitative computed tomography (QCT) scan of the upper abdomen. The scanning parameters are as follows: 120 kVp at all centers, mAs between 75 and 200, FOV 40 cm×40 cm. The BMD values of L1 to L3 are measured, and the average BMD calculated. The American College of Radiology QCT criteria for the diagnosis of osteoporosis is applied to determine the presence of osteoporosis. The scout view images of T4-L4 vertebrae are reviewed by two experienced radiologists for semi-quantification of vertebral fractures according to Genant's method. |
| Databáze: | OpenAIRE |
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