The interplay of signaling pathway in endothelial cells-matrix stiffness dependency with targeted-therapeutic drugs

Autor: Vicki Vania, Youhua Tan, Guixue Wang, Tao Zhang, Juhui Qiu, Lu Wang, Marco Tjakra
Rok vydání: 2019
Předmět:
0301 basic medicine
RHOA
030204 cardiovascular system & hematology
Vascular Remodeling
03 medical and health sciences
Mechanobiology
0302 clinical medicine
Vascular Stiffness
medicine
Animals
Humans
Endothelial dysfunction
Protein kinase A
Molecular Biology
Protein Kinase Inhibitors
Randomized Controlled Trials as Topic
Mitogen-Activated Protein Kinase Kinases
Hippo signaling pathway
Cell chemotaxis
rho-Associated Kinases
biology
business.industry
Endothelial Cells
medicine.disease
Atherosclerosis
Elasticity
Extracellular Matrix
Endothelial stem cell
Disease Models
Animal
030104 developmental biology
Treatment Outcome
biology.protein
Molecular Medicine
Endothelium
Vascular
Signal transduction
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
rhoA GTP-Binding Protein
Neuroscience
Signal Transduction
Zdroj: Biochimica et biophysica acta. Molecular basis of disease. 1866(5)
ISSN: 1879-260X
Popis: Cardiovascular diseases (CVDs) have been one of the major causes of human deaths in the world. The study of CVDs has focused on cell chemotaxis for decades. With the advances in mechanobiology, accumulating evidence has demonstrated the influence of mechanical stimuli on arterial pathophysiology and endothelial dysfunction that is a hallmark of atherosclerosis development. An increasing number of drugs have been exploited to decrease the stiffness of vascular tissue for CVDs therapy. However, the underlying mechanisms have yet to be explored. This review aims to summarize how matrix stiffness mediates atherogenesis through various important signaling pathways in endothelial cells and cellular mechanophenotype, including RhoA/Rho-associated protein kinase (ROCK), mitogen-activated protein kinase (MAPK), and Hippo pathways. We also highlight the roles of putative mechanosensitive non-coding RNAs in matrix stiffness-mediated atherogenesis. Finally, we describe the usage of tunable hydrogel and its future strategy to improve our knowledge underlying matrix stiffness-mediated CVDs mechanism.
Databáze: OpenAIRE
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