Exploring the molecular targets and mechanisms of [10]-Gingerol for treating triple-negative breast cancer using bioinformatics approaches, molecular docking, and in vivo experiments
| Autor: | Yan Dai, Yuqi Liang, Qianqian Guo, Ping Huang, Jiahua Wu, Rui Xu, Hai Lu, Guosong Wu, Qianjun Chen, Peijuan Zhou |
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| Rok vydání: | 2021 |
| Předmět: |
natural product
Cancer Research Chemistry Gingerol apoptosis molecular docking Computational biology chemistry.chemical_compound Oncology In vivo Triple-negative breast cancer (TNBC) Molecular targets network pharmacology Original Article Radiology Nuclear Medicine and imaging [10]-Gingerol Triple-negative breast cancer |
| Zdroj: | Translational Cancer Research |
| ISSN: | 2219-6803 2218-676X |
| DOI: | 10.21037/tcr-21-1138 |
| Popis: | Background Triple-negative breast cancer (TNBC) is the most aggressive among breast cancer subtypes with the worst prognosis. Ginger is widely used in pharmaceuticals and as food. Its anticancer properties are known, but the mechanism is still unclear. [10]-Gingerol is one of the main phenolic compounds isolated from ginger. Studying the biological effects of [10]-Gingerol is of great significance to understand the efficacy of ginger. Methods In this study, the therapeutic effects of [10]-Gingerol on TNBC cells were studied using network pharmacology, molecular docking, and in vitro experiments, and the target and mechanism of action were explained. Results A total of 48 targets of ginger for the treatment of TNBC were found. These targets might interfere with the growth of TNBC by participating in many pathways, such as endocrine resistance, progesterone-mediated oocyte maturation, estrogen signaling pathway, and cellular senescence. Prognostic analyses indicated that the JUN, FASN, ADRB2, ADRA2A, and PGR were the hub genes, while molecular docking predicted the stable binding of ADRB2 protein with drug compounds. Additionally, [10]-Gingerol could induce apoptosis by regulating the caspase activation. Conclusions [10]-Gingerol affects the growth of TNBC through multiple action targets and participating in multiple action pathways. ADRB2 and apoptosis pathways might be important target pathways for [10]-Gingerol in the treatment of TNBC. |
| Databáze: | OpenAIRE |
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