Improved photodynamic efficacy of thiophenyl sulfonated zinc phthalocyanine loaded in lipid nano-carriers for hepatocellular carcinoma cancer cells
| Autor: | Ghada M. Al-Toukhy, Hanan H. Mohamed, Tamer E. Youssef, Doaa A. Abdel Fadeel, Asma M. Elsharif, Suhailah S. Al-Jameel |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Carcinoma
Hepatocellular Indoles Cell Survival medicine.medical_treatment Biophysics chemistry.chemical_element Photodynamic therapy 02 engineering and technology Dermatology Zinc Isoindoles 010402 general chemistry 01 natural sciences chemistry.chemical_compound Drug Delivery Systems Organometallic Compounds medicine Humans Pharmacology (medical) Particle Size Photosensitizing Agents Liver Neoplasms Cancer Hep G2 Cells 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Photochemotherapy Oncology chemistry Zinc Compounds Hepatocellular carcinoma Liposomes Cancer cell Phthalocyanine Nanoparticles 0210 nano-technology Liver cancer Phototoxicity Nuclear chemistry |
| Zdroj: | Photodiagnosis and Photodynamic Therapy. 23:25-31 |
| ISSN: | 1572-1000 |
| Popis: | Background The aim of the present study was to modify the structural activity of zinc(II)phthalocyanine by combining it with thiophenyl groups then loaded in lipid nano-carriers and evaluate its parameters required for the structure-activity relationship (SAR) for photodynamic therapy (PDT) of cancer. Methods Tetra (4–Thiophenyl) sulfonated phthalocyaninatozinc(II) (PhS·SO3Na)4ZnPc 5 was synthesized and characterized by various spectroscopic methods as a test compound. Liver hepatocellular carcinoma (HepG2) cells were treated with the synthesized (PhS·SO3Na)4ZnPc 5 derivative loaded in lipid nano carriers to understand the effect of combined compound on liver cancer cells. Furthermore, HepG2 cells were irradiated by visible red light at 60 mW/cm2 for 20 min. The phototoxicity of (PhS·SO3Na)4ZnPc 5 after being formulated in both (L) and transfersomes (T) was investigated. Results Overall, the results indicate that combination of thiophenyl groups substitution, in particular in the structure of sulfonated zinc phthalocyanine is able to improve the photodynamic properties of ZnPc, and (PhS·SO3Na)4ZnPc 5 loaded in lipid nano-carriers can be a promising combined PDT treatment strategy for Liver hepatocellular carcinoma (HepG2) cells. Conclusions The new formulation ZnPc-lipid nano-carriers will be beneficial in the upcoming clinical trials and would enhance the inhibition of tumor growth. |
| Databáze: | OpenAIRE |
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