Increase of T lymphocytes in the spleen in Hodgkin's disease
| Autor: | A.S.D. Spiers, David A. G. Galton, Daniel Catovsky, Juginder Kaur |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Biopsy T-Lymphocytes Fluorescent Antibody Technique Immunoglobulins Spleen Disease Lymphocyte Activation Leukocyte Count Lectins medicine Animals Humans Normal range Hodgkin s B-Lymphocytes Blood Specimen Collection Immunity Cellular Sheep biology business.industry Relative distribution Cell Membrane General Medicine Organ Size Middle Aged Hodgkin Disease Peripheral blood Immune Adherence Reaction Immunoglobulin A medicine.anatomical_structure Immunoglobulin M Immunoglobulin G Immunology biology.protein Splenectomy Female Antibody business |
| Zdroj: | Lancet (London, England). 2(7884) |
| ISSN: | 0140-6736 |
| Popis: | Spleen and peripheral-blood lymphocytes from ten patients with Hodgkin's disease have been studied for the relative distribution of T and B lymphocytes. Nine patients were untreated and eight had nodular sclerosing Hodgkin's disease. The response of lymphocytes to phyto-haemagglutinin (P.H.A.) after 72 hours in culture, and their capacity to form rosettes with sheep red blood-cells, were used as indicators for T-lymphocyte function and surface-bound immunoglobulins as a marker for B lymphocytes. In the spleens the mean percentage of T lymphocytes (P.H.A.-responsive cells) was significantly higher (67%) than that in the non-malignant spleens (28%). In the peripheral blood the proportion of T and B lymphocytes was within the normal range. In addition, the mean percentage of spontaneously transformed lymphocytes in the cultures of splenic lymphocytes was significantly higher in Hodgkin's disease than in non-malignant diseases. These findings may indicate an immunological reaction in the spleens of patients with Hodgkin's disease. |
| Databáze: | OpenAIRE |
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