Surprisingly high prevalence of subtype C and specific HIV-1 subtype/CRF distribution in men having sex with men in Senegal
| Autor: | Martine Peeters, Souleymane Mboup, Tandakha Ndiaye Dieye, Nicole Vidal, Coumba Toure-Kane, Abdoulaye Sidibe Wade, Aïssatou Gaye-Diallo, Halimatou Diop Ndiaye, Fabien R. Niama, Pape Amadou Niang-Diallo |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Genotype Population Human immunodeficiency virus (HIV) Sequence Homology HIV Infections medicine.disease_cause Men who have sex with men Young Adult Epidemiology medicine Prevalence Cluster Analysis Humans Pharmacology (medical) Young adult Homosexuality Male education Phylogeny education.field_of_study Molecular Epidemiology Molecular epidemiology biology business.industry virus diseases Sequence Analysis DNA biology.organism_classification Virology Senegal Infectious Diseases pol Gene Products Human Immunodeficiency Virus Lentivirus HIV-1 business |
| Zdroj: | Journal of acquired immune deficiency syndromes (1999). 52(2) |
| ISSN: | 1944-7884 |
| Popis: | BACKGROUND: Recent reports showed the high vulnerability for HIV infection of men who have sex with men (MSM) in Africa. Here, we report the HIV-1 variants that circulate among MSM in Senegal. METHODS: HIV-1 subtype/circulating recombinant form (CRF) was determined in an 1800-base pair fragment of pol for 70 HIV-1-positive samples from MSM. Phylogenetic trees were constructed using the neighbor-joining method with CLUSTALX. Similarity and bootstrap plots were then done for recombination analysis. The maximum likelihood approach was used for the identification of transmission clusters. RESULTS: Sixty-seven samples (95%) were from Senegalese MSM, 90% unmarried with a median age of 30 years. Fifty-five MSM had regular male partners, but 39 of 70 had also a regular female partner. The overall subtype/CRF distribution was as follows: 28 C (40%), 17 CRF02_AG (24.3%), 13 B (18.6%), 6 G (8.6%), 3 CRF09_cpx (4.3%), and 3 (4.3%) unique recombinants. In addition, 47 sequences (67.15%) were segregated into 15 transmission clusters. CONCLUSIONS: These variants circulate also among the general population or female sex workers, but the proportions are significantly different. Despite the massive stigma, the majority (80%) of MSM recognized having sex with women and could serve as a bridge for intermixing of HIV-1 variants between high-risk men and low-risk women. |
| Databáze: | OpenAIRE |
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