Plasma β-III tubulin, neurofilament light chain and glial fibrillary acidic protein are associated with neurodegeneration and progression in schizophrenia
| Autor: | Elena de Las Heras, Alejandro García-Caballero, María Del Carmen Vallejo-Curto, Patricia Fernández-Palleiro, José Manuel Olivares, Marta López, Tania Rivera-Baltanás, Carlos Spuch, Daniela Rodrigues-Amorim, Carolina Barreiro-Villar, María Álvarez-Ariza, Maria Blanco-Formoso, Cynthia Rodriguez-Jamardo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Psychosis medicine.medical_specialty Neurofilament light 3211 Psiquiatría lcsh:Medicine Predictive markers Article 03 medical and health sciences β iii tubulin 6106.07 Procesos Mentales 0302 clinical medicine Neurofilament Proteins Tubulin Internal medicine Glial Fibrillary Acidic Protein medicine Humans lcsh:Science Psychiatric Status Rating Scales Multidisciplinary Glial fibrillary acidic protein biology business.industry Neurodegeneration lcsh:R Brain Plasma levels medicine.disease 030104 developmental biology Endocrinology 3208 Farmacodinámica Schizophrenia Case-Control Studies biology.protein Disease Progression lcsh:Q Female business 030217 neurology & neurosurgery Antipsychotic Agents |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Schizophrenia is a progressive disorder characterized by multiple psychotic relapses. After every relapse, patients may not fully recover, and this may lead to a progressive loss of functionality. Pharmacological treatment represents a key factor to minimize the biological, psychological and psychosocial impact of the disorder. The number of relapses and the duration of psychotic episodes induce a potential neuronal damage and subsequently, neurodegenerative processes. Thus, a comparative study was performed, including forty healthy controls and forty-two SZ patients divided into first-episode psychosis (FEP) and chronic SZ (CSZ) subgroups, where the CSZ sub group was subdivided by antipsychotic treatment. In order to measure the potential neuronal damage, plasma levels of β-III tubulin, neurofilament light chain (Nf-L), and glial fibrillary acidic protein (GFAP) were performed. The results revealed that the levels of these proteins were increased in the SZ group compared to the control group (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|