Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance
| Autor: | Pensri Pootrakul, John K. Olynyk, Timothy G. St. Pierre, Paul R. Clark, Robert Lindeman, Gary P. Jeffrey, Adam J. Fleming, Wanida Chua-anusorn, Erin Robins |
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| Rok vydání: | 2005 |
| Předmět: |
Liver Iron Concentration
Iron Overload Materials science Proton Calibration curve Biopsy Iron Coefficient of variation Immunology Sensitivity and Specificity Biochemistry Paramagnetism Chlorides medicine Humans medicine.diagnostic_test Phantoms Imaging business.industry Reproducibility of Results Magnetic resonance imaging Cell Biology Hematology Magnetic Resonance Imaging Liver Manganese Compounds Hereditary hemochromatosis Protons Nuclear medicine business |
| Zdroj: | Blood. 105:855-861 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | Measurement of liver iron concentration (LIC) is necessary for a range of iron-loading disorders such as hereditary hemochromatosis, thalassemia, sickle cell disease, aplastic anemia, and myelodysplasia. Currently, chemical analysis of needle biopsy specimens is the most common accepted method of measurement. This study presents a readily available noninvasive method of measuring and imaging LICs in vivo using clinical 1.5-T magnetic resonance imaging units. Mean liver proton transverse relaxation rates (R2) were measured for 105 humans. A value for the LIC for each subject was obtained by chemical assay of a needle biopsy specimen. High degrees of sensitivity and specificity of R2 to biopsy LICs were found at the clinically significant LIC thresholds of 1.8, 3.2, 7.0, and 15.0 mg Fe/g dry tissue. A calibration curve relating liver R2 to LIC has been deduced from the data covering the range of LICs from 0.3 to 42.7 mg Fe/g dry tissue. Proton transverse relaxation rates in aqueous paramagnetic solutions were also measured on each magnetic resonance imaging unit to ensure instrument-independent results. Measurements of proton transverse relaxivity of aqueous MnCl2 phantoms on 13 different magnetic resonance imaging units using the method yielded a coefficient of variation of 2.1%. |
| Databáze: | OpenAIRE |
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