Relative Contribution of Morphometric and Functional Indicators of Tubulointerstitial Lesion to Glomerular Diseases Prognosis
| Autor: | Gianna Mastroianni Kirsztajn, Rogério Barbosa de Deus, Vicente de Paulo Castro Teixeira |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Nephrology Pathology medicine.medical_specialty Urine Kidney Sensitivity and Specificity Lesion Internal medicine medicine Humans business.industry fungi Reproducibility of Results food and beverages Glomerulonephritis General Medicine Prognosis medicine.disease Retinol-Binding Proteins Retinol binding protein Nephritis Interstitial Female Kidney Diseases medicine.symptom business Nephritis Biomarkers Tubulointerstitial lesion Kidney disease |
| Zdroj: | Nephron Clinical Practice. 110:c164-c171 |
| ISSN: | 1660-2110 |
| DOI: | 10.1159/000166992 |
| Popis: | Background: Early diagnosis of proximal tubular lesions can be achieved by detecting abnormal levels of low molecular weight proteins in urine. Material and Methods: 100 cases of glomerulopathies were retrospectively studied to establish the profile of urinary levels of retinol-binding protein (urRBP) and their correlation with histological markers of tubulointerstitial lesions in renal biopsies. The histological study included staining with picrosirius red. Results: Nonproliferative glomerulopathies, male sex, white race and young adults were predominant. The chance of abnormal urRBP occurring was higher among patients with a predominant proliferative component, baseline serum creatinine >1.2 mg/dl (p = 0.008), creatinine clearance Conclusion: Our study suggests that urRBP determination is prognostically relevant in the progression of glomerulopathies; on the other hand, the evaluated morphometric markers correlated poorly with the clinical outcome of these patients. Consequently, urRBP determination, as a functional marker of tubulointerstitial damage, was more appropriate for determining the prognosis of glomerular diseases than the morphometric analysis of renal biopsies. |
| Databáze: | OpenAIRE |
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