Effects of medical ozone therapy on acetaminophen-induced nephrotoxicity in rats

Autor:	Bulent Uysal, Mehmet Ozler, Umit Kaldirim, Ahmet Korkmaz, Tuncer Cayci, Ayhan Ozcan, Ahmet Guven, Suzi Demirbag, İlhami Sürer
Rok vydání:	2010
Předmět:	Male Pharmacology Kidney Kidney Function Tests Critical Care and Intensive Care Medicine Statistics Nonparametric Nephrotoxicity chemistry.chemical_compound Ozone Animals Medicine Rats Wistar Toxication Acetaminophen chemistry.chemical_classification Creatinine business.industry Glutathione peroxidase digestive oral and skin physiology General Medicine Ozone therapy Malondialdehyde Rats Oxidative Stress medicine.anatomical_structure chemistry Nephrology Kidney Diseases Spectrophotometry Ultraviolet business medicine.drug
Zdroj:	Renal Failure. 32:493-497
ISSN:	1525-6049 0886-022X
DOI:	10.3109/08860221003646352
Popis:	Acetaminophen (APAP), also known as paracetamol, is the commonest cause of toxic ingestion in the world. Because overdose of APAP has life-threatening effects on kidney, treatment of APAP-induced nephrotoxicity has life-saving importance. Aim of the study was to evaluate the efficacy of medical ozone therapy in experimental model of APAP toxication. Twenty-one male Wistar rats (200-250 g) were randomly assigned into three groups containing seven rats each: Sham, control (only APAP treated), and APAP + ozone therapy groups. Rats were killed 48 hours after administration of APAP. Urea, creatinine levels in the blood, and malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity in renal tissue were measured. Kidney tissues were stained with hematoxylin and eosin for histological assessment. APAP administration deteriorated the renal functions and significantly elevated renal MDA levels and depleted SOD and GSH-Px activities. Ozone therapy significantly reduced the MDA level, increased the SOD and GSH-Px activities, and normalized the renal histology. In conclusion, our study results are consistent with encouraging data for ozone therapy on APAP-induced nephrotoxicity in rats by improving antioxidant mechanism and oxidative stress.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e890653a87e470afef32b9bab0fbc2b6 https://doi.org/10.3109/08860221003646352 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.