Clinical manifestations of neurological involvement in primary Sjögren’s syndrome
Autor: | Akiko Tochimoto, Yasuhiro Katsumata, Yuko Ota, Yasushi Kawaguchi, Yuko Okamoto, Hisashi Yamanaka, Takahisa Gono, Sayumi Baba, Kae Takagi |
---|---|
Rok vydání: | 2010 |
Předmět: |
Adult
Male Nervous system Pathology medicine.medical_specialty Nerve fiber Rheumatology Central Nervous System Diseases Trigeminal neuralgia medicine Humans Optic neuritis Retrospective Studies medicine.diagnostic_test business.industry Peripheral Nervous System Diseases General Medicine Middle Aged medicine.disease eye diseases stomatognathic diseases Sjogren's Syndrome medicine.anatomical_structure Peripheral nervous system Nerve conduction study Female business Vasculitis Polyneuropathy |
Zdroj: | Clinical Rheumatology. 30:485-490 |
ISSN: | 1434-9949 0770-3198 |
Popis: | The aim of this study was to evaluate neurological manifestations of primary Sjögren’s syndrome (pSS) and investigate the etiology and pathogenesis of peripheral and central nervous complications in pSS. Thirty-two patients with pSS were enrolled in the present study, 20 of whom had neurological involvement plus sicca symptoms. The clinical features were evaluated by neurological examinations including nerve conduction study, magnetic resonance imaging, cerebrospinal fluid, and electroencephalogram. The frequency of fever was significantly higher (P = 0.006) in pSS with neurological involvement than in pSS without neurological involvement. There was no statistical significance in other factors between the two groups. Peripheral nervous system (PNS), central nervous system (CNS), and both PNS and CNS involvements were revealed in 14, 3, and 3 patients, respectively. Optic neuritis and trigeminal neuralgia were revealed frequently in cranial neuropathy. Anti-aquaporin 4 antibody was detected in one patient with optic neuritis. Of the nine patients with polyneuropathy, eight patients presented pure sensory neuropathy including small fiber neuropathy (SFN). pSS with SFN appeared to have no clinically abnormal features, including muscle weakness and decreasing deep tendon reflex. Skin biopsy revealed epidermal nerve fiber degenerated in one pSS patient with pure sensory neuropathy who was diagnosed as having SFN. Our observations suggest that a number of mechanisms can be attributed to neurological involvements in pSS rather than just the mechanisms previously described (i.e., vasculitis and ganglioneuronitis). Presumably, specific autoantibodies may directly induce injury of the nervous system. |
Databáze: | OpenAIRE |
Externí odkaz: |