Elevations in Thyroid-Stimulating Hormone in Normal Subjects after Receiving Short-Term Lithium Carbonate
| Autor: | R. L. Evans, M. V. Nelson, V. Tutag-Lehr |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Time Factors endocrine system diseases Lithium (medication) Thyrotropin Lithium 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lithium Carbonate Thyroid-stimulating hormone Oral administration Internal medicine Blood plasma Humans Medicine Pharmacology (medical) 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Volunteer biology business.industry Lithium carbonate biology.organism_classification 030227 psychiatry Endocrinology chemistry Tasa business hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | Drug Intelligence & Clinical Pharmacy. 22:202-204 |
| ISSN: | 0012-6578 |
| DOI: | 10.1177/106002808802200304 |
| Popis: | Nine normal, healthy male subjects had significantly elevated thyroid-stimulating hormone (TSH) concentrations while receiving oral lithium carbonate for two weeks. The mean minimum lithium serum concentration was 0.765 mEq/L. The TSH concentrations after 15 days on lithium were significantly correlated to the TSH concentration at baseline. No correlation was found between mean minimum lithium steady-state concentration and TSH concentration after 15 days on lithium. Further research is necessary to determine if a high baseline TSH concentration or an early rise in TSH will predict those patients who will eventually develop hypothyroidism after long-term lithium therapy. |
| Databáze: | OpenAIRE |
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