Adult-Onset Immunodeficiency in Thailand and Taiwan
| Autor: | Ploenchan Chetchotisakd, Piroon Mootsikapun, Paul Saleeb, Jennifer L. Kirk, Camilla Dacombe, Adrian M. Zelazny, Lindsey B. Rosen, Amy P. Hsu, Reginald J. Claypool, Viraphong Lulitanond, Boonmee Sathapatayavongs, Charin Thepthai, Siriluck Anunnatsiri, Peter D. Burbelo, Yona Reizes, Chi Chang Shieh, Duangdao Waywa, Wanna Thongnoppakhun, Nasikarn Angkasekwinai, Li Ding, Allen Mo, Elizabeth P. Sampaio, Smita Y. Patel, Po-Ren Hsueh, Yupin Suputtamongkol, Kamonwan Jutivorakool, Pamela A. Shaw, Kenneth N. Olivier, Sasisopin Kiertiburanakul, Rifat Zaman, Steven M. Holland, Margaret R. Brown, Sarah K. Browne, Michael J. Iadarola |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Tuberculosis Adolescent Opportunistic infection Taiwan Opportunistic Infections Article Autoimmune Diseases Interferon-gamma Young Adult medicine Humans Interferon gamma Age of Onset Young adult Tuberculosis Pulmonary Immunodeficiency Aged Autoantibodies Mycobacterium Infections biology business.industry Autoantibody General Medicine Middle Aged Thailand medicine.disease Antibodies Neutralizing CD4 Lymphocyte Count Mycoses Immunology biology.protein Female Age of onset Antibody business medicine.drug |
| Zdroj: | New England Journal of Medicine. 367:725-734 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejmoa1111160 |
| Popis: | Autoantibodies against interferon-γ are associated with severe disseminated opportunistic infection, but their importance and prevalence are unknown.We enrolled 203 persons from sites in Thailand and Taiwan in five groups: 52 patients with disseminated, rapidly or slowly growing, nontuberculous mycobacterial infection (group 1); 45 patients with another opportunistic infection, with or without nontuberculous mycobacterial infection (group 2); 9 patients with disseminated tuberculosis (group 3); 49 patients with pulmonary tuberculosis (group 4); and 48 healthy controls (group 5). Clinical histories were recorded, and blood specimens were obtained.Patients in groups 1 and 2 had CD4+ T-lymphocyte counts that were similar to those in patients in groups 4 and 5, and they were not infected with the human immunodeficiency virus (HIV). Washed cells obtained from patients in groups 1 and 2 had intact cytokine production and a response to cytokine stimulation. In contrast, plasma obtained from these patients inhibited the activity of interferon-γ in normal cells. High-titer anti-interferon-γ autoantibodies were detected in 81% of patients in group 1, 96% of patients in group 2, 11% of patients in group 3, 2% of patients in group 4, and 2% of controls (group 5). Forty other anticytokine autoantibodies were assayed. One patient with cryptococcal meningitis had autoantibodies only against granulocyte-macrophage colony-stimulating factor. No other anticytokine autoantibodies or genetic defects correlated with infections. There was no familial clustering.Neutralizing anti-interferon-γ autoantibodies were detected in 88% of Asian adults with multiple opportunistic infections and were associated with an adult-onset immunodeficiency akin to that of advanced HIV infection. (Funded by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research; ClinicalTrials.gov number, NCT00814827.). |
| Databáze: | OpenAIRE |
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