Elevated plasma chemokine CCL18/PARC in beta-thalassemia
| Autor: | S Altun, J. Sarafidou, Marina Moraitou, E. Dimitriou, Helen Michelakakis, H Aerts, Fotis Karabatsos, Rolf G. Boot, Jacqueline Youssef, Marri Verhoek, Markissia Karagiorga |
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| Přispěvatelé: | Amsterdam Gastroenterology Endocrinology Metabolism, Medical Biochemistry, Amsterdam Cardiovascular Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Chemokine Adolescent Gastroenterology Internal medicine Genotype medicine Humans In patient Child Molecular Biology Gaucher Disease biology Greece business.industry beta-Thalassemia Wild type CCL18 Infant Newborn Beta thalassemia Infant Cell Biology Hematology Middle Aged medicine.disease Ferritin Hexosaminidases Chemokines CC Child Preschool Immunology Cohort biology.protein Molecular Medicine business |
| Zdroj: | Blood cells, molecules & diseases, 35(3), 328-331. Academic Press Inc. ResearcherID |
| ISSN: | 1079-9796 |
| Popis: | Plasma CCL18/PARC, a member of the CC chemokine family, has been found to be several ten-fold increased in symptomatic Gaucher type I patients. Elevated plasma chitotriosidase levels are a well-known abnormality in Gaucher patients, however, its diagnostic use is limited by the frequent genetic deficiency in the protein. Like the situation in Gaucher disease, lipids accumulate in macrophages of patients suffering from beta-thalassemia, and, in both conditions, increased chitotriosidase levels occur. We here report that plasma CCL18/PARC is also significantly increased in patients with beta-thalassemia major (range 76.8-4977.8, median=650.8 ng/ml, n=36 and control range 10-72, median=33 ng/ml n=36 respectively, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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