Poly-L-Lactic Acid β-Tricalcium Phosphate Screws: A Preliminary In Vivo Biocompatibility Study
| Autor: | D. Palmieri, R. Zappacosta, Nicola Magarelli, C. Orso, Vincenzo Salini, Giuseppe Guglielmi, Cesare Colosimo, G. Lattanzio, Massimo Savastano |
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| Přispěvatelé: | Magarelli, N, Savastano, Ma, Palmieri, D, Zappacosta, R, Lattanzio, G, Salini, V, Orso, Ca, Guglielmi, G, Colosimo, C. |
| Rok vydání: | 2007 |
| Předmět: |
Calcium Phosphates
musculoskeletal diseases Poly l lactic acid Biocompatibility Polymers Polyesters Bone Screws Immunology Biocompatible Materials Bone and Bones In vivo biocompatibility 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Beta-tricalcium phosphate Left femur Absorbable Implants Materials Testing Animals Polymethyl Methacrylate Immunology and Allergy Femur Lactic Acid Titanium Pharmacology Sheep Chemistry Bone Cements Lactic acid Bone screws 030220 oncology & carcinogenesis 030215 immunology Biomedical engineering |
| Zdroj: | International Journal of Immunopathology and Pharmacology. 20:207-211 |
| ISSN: | 2058-7384 |
| DOI: | 10.1177/039463200702000126 |
| Popis: | The aim of this study is to assess the biocompatibility of two types of Poly-L-lactic acid (PLLA) screws (with either hydroxiapatite (HA) or β-tricalcium phosphate (β-TCP)) implanted in the left femur of four sheep euthanized at 42, 50, 57 and 84 days after surgery. Titanium screws were also implanted for comparison purposes. No signs of inflammation were seen in the 240 specimens. A rating of “+/-”for macrophages and “-”for neutrophils was assigned to all specimens. All specimens were assigned a rating which ranged from “+/-” to “+++” for fibroblasts and osteoblasts. The presence of macrophages, neutrophils and fibroblasts/osteoblasts was not statistically different for the four implantation periods. PLLA implants with β-TCP have a biocompatibility comparable to PLLA implants with HA. |
| Databáze: | OpenAIRE |
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