Lebectin increases N-cadherin-mediated adhesion through PI3K/AKT pathway
Autor: | Mohamed El Ayeb, Naziha Marrakchi, Carole Siret, Frédéric André, Sameh Sarray, José Luis, Maxime Lehmann |
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Přispěvatelé: | Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP), Faculté des Sciences, Faculté des Sciences Mathématiques, Physiques et Naturelles de Tunis (FST), Université de Tunis El Manar (UTM)-Université de Tunis El Manar (UTM), Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM) |
Rok vydání: | 2009 |
Předmět: |
MESH: Signal Transduction
Cancer Research MESH: Cell Line Tumor Blotting Western Integrin Viper Venoms Biology MESH: Cadherins MESH: Cell Adhesion Phosphatidylinositol 3-Kinases 03 medical and health sciences 0302 clinical medicine Cell–cell interaction Cell Movement Cell Line Tumor Cell Adhesion Humans Immunoprecipitation MESH: Blotting Western Lectins C-Type CD93 Cell adhesion MESH: Cell Movement 030304 developmental biology 0303 health sciences MESH: Humans MESH: Proto-Oncogene Proteins c-akt MESH: Immunoprecipitation Cell adhesion molecule Cadherin MESH: Immunohistochemistry Cadherins Intercellular adhesion molecule Immunohistochemistry 3. Good health Cell biology Oncology MESH: Phosphatidylinositol 3-Kinases 030220 oncology & carcinogenesis biology.protein [SDV.IMM]Life Sciences [q-bio]/Immunology Neural cell adhesion molecule MESH: Viper Venoms Proto-Oncogene Proteins c-akt MESH: Lectins C-Type Signal Transduction |
Zdroj: | Cancer Letters Cancer Letters, Elsevier, 2009, 285 (2), pp.174-81. ⟨10.1016/j.canlet.2009.05.012⟩ |
ISSN: | 0304-3835 |
Popis: | International audience; Cell adhesion molecules, including cadherins and integrins, play an essential role during tumor progression and represent potential targets for the development of new therapeutic agents. We previously showed that lebectin, a C-type lectin protein (CLP) issued from Macrovipera lebectina snake venom, inhibits integrin-mediated migration of IGR39 melanoma cells. Here we assessed whether lebectin modulates cell-cell adhesion. We demonstrated that lebectin promotes N-cadherin/catenin complex reorganization at cell-cell contacts, inducing a strengthening of intercellular adhesion. This reorganization is associated to phosphorylation of beta-catenin on tyrosine 142 residue. Interestingly, lebectin acts on N-cadherin-mediated cell-cell contacts through PI3K/Akt pathway. This effect could contribute to the blockage of tumor cell migration previously observed. |
Databáze: | OpenAIRE |
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