In vitro antitrypanosomal activity of the cyclodepsipeptides, cardinalisamides A–C, from the insect pathogenic fungus Cordyceps cardinalis NBRC 103832
| Autor: | Toshio Kumada, Kazuhiko Otoguro, Mina Shimizu, Aki Ishiyama, Akemi Umeyama, Koichi Takahashi, Sayaka Ban, Aleksandra Grudniewska, Toshihiro Hashimoto, Masayuki Kato, Satoshi Omura, Masato Iwatsuki, Yasuko Okamoto, Midori Suenaga, Sayaka Hayashi |
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| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
biology Stereochemistry media_common.quotation_subject Trypanosoma brucei brucei Insect Trypanosoma brucei Pathogenic fungus biology.organism_classification Trypanocidal Agents In vitro Lepidoptera Trypanosomiasis African Cordyceps cardinalis Depsipeptides Cordyceps Drug Discovery Ic50 values Animals Humans Antitrypanosomal drug media_common |
| Zdroj: | The Journal of Antibiotics. 67:163-166 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.1038/ja.2013.93 |
| Popis: | During the search for new antitrypanosomal drug leads, three new antitrypanosomal compounds, cardinalisamides A-C (1-3), were isolated from cultures of the insect pathogenic fungus Cordyceps cardinalis NBRC 103832. Their structures were elucidated using MS analyses and extensive 2D-heteronuclear NMR. The absolute configurations of 1-3 were addressed by chemical degradation and Marfey's analysis. 1-3 showed in vitro antitrypanosomal activity against Trypanosoma brucei brucei with IC50 values of 8.56, 8.65 and 8.63 μg ml(-1), respectively. |
| Databáze: | OpenAIRE |
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