Personalised medicine in sleep respiratory disorders: focus on obstructive sleep apnoea diagnosis and treatment
| Autor: | Josep M. Montserrat, Monique C. Suarez Giron, Oreste Marrone, Maria R. Bonsignore, Alessandra Castrogiovanni |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty medicine.medical_treatment MEDLINE Comorbidity Disease 03 medical and health sciences 0302 clinical medicine stomatognathic system Predictive Value of Tests Risk Factors Humans Medicine Continuous positive airway pressure Precision Medicine Intensive care medicine Lung lcsh:RC705-779 Sleep Apnea Obstructive business.industry Respiration Sleep apnea lcsh:Diseases of the respiratory system medicine.disease Sleep in non-human animals nervous system diseases respiratory tract diseases 3. Good health Treatment Outcome 030228 respiratory system Physical therapy Positional Treatment Sleep business Airway 030217 neurology & neurosurgery |
| Zdroj: | European Respiratory Review, Vol 26, Iss 146 (2017) |
| ISSN: | 1600-0617 0905-9180 |
| DOI: | 10.1183/16000617.0069-2017 |
| Popis: | In all fields of medicine, major efforts are currently dedicated to improve the clinical, physiological and therapeutic understanding of disease, and obstructive sleep apnoea (OSA) is no exception. The personalised medicine approach is relevant for OSA, given its complex pathophysiology and variable clinical presentation, the interactions with comorbid conditions and its possible contribution to poor outcomes. Treatment with continuous positive airway pressure (CPAP) is effective, but CPAP is poorly tolerated or not accepted in a considerable proportion of OSA patients. This review summarises the available studies on the physiological phenotypes of upper airway response to obstruction during sleep, and the clinical presentations of OSA (phenotypes and clusters) with a special focus on our changing attitudes towards approaches to treatment. Such major efforts are likely to change and expand treatment options for OSA beyond the most common current choices (i.e. CPAP, mandibular advancement devices, positional treatment, lifestyle changes or upper airway surgery). More importantly, treatment for OSA may become more effective, being tailored to each patient's need. |
| Databáze: | OpenAIRE |
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