The Clinical Assessment of Ischaemia Modified Albumin and Troponin I in the Early Diagnosis of the Acute Coronary Syndrome
| Autor: | M.P. Banker, Ramchandra K. Padalkar, Sangita M. Patil, Rahul A Ghone, Anjali S. Phatake, Sonali S. Bhagat, Abhijit P. Pathak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Acute coronary syndrome Clinical Biochemistry lcsh:Medicine Chest pain acute coronary syndrome Internal medicine Troponin I medicine Myocardial infarction cardiovascular diseases Receiver operating characteristic biology Unstable angina business.industry lcsh:R Albumin ischaemia modified albumin General Medicine medicine.disease Troponin myocardial ischaemia Cardiology biology.protein troponin i Original Article medicine.symptom business |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 7, Iss 5, Pp 804-808 (2013) |
| Popis: | Background: An early identification of the patients with the Acute Coronary Syndrome (ACS) is of prime importance, due to the associated very high mortality. Only about 22% of the patients who present at the emergency cardiology care centres with chest pain, have coronary disease. Ischaemia modified albumin has already been licensed by the US Food and Drug Administration for the diagnosis of suspected myocardial ischaemia. Aim: The goal of the present study was to assess the diagnostic value of serum ischaemia modified albumin and to compare it with sensitive cardiac troponin I in patients with the acute coronary syndromes like unstable angina and acute myocardial infarction. Methods: A diagnostic case control study was conducted on 102 patients who presented to the Emergency Department within 6 hrs of having acute chest pain and on 110 healthy age and sex matched volunteers who formed the control group. The serum Ischaemia Modified Albumin level was estimated by the albumin cobalt binding test by using a digital spectrophotometer, while Troponin I was measured by doing an immunofluroscence assay. A receiver operating characteristic curve was established for ischaemia modified albumin, to determine the cut-off point. The sensitivity and the specificity of ischaemia modified albumin and troponin I for the detection of acute coronary syndromes, were analyzed. The results of ischaemia modified albumin and troponin I alone and in combination, were correlated. Results: The ischaemia modified albumin (p |
| Databáze: | OpenAIRE |
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