Increased Incidence and Mortality Associated With Skin Cancers After Cardiac Transplant
| Autor: | D. H. Silber, Murad Alam, David S. Feldman, G. M. Mullen, R. M. Oren, Robert N. Brown, Clyde W. Yancy |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Skin Neoplasms Population Kaplan-Meier Estimate Organ transplantation Cohort Studies Risk Factors Internal medicine medicine Carcinoma Humans Immunology and Allergy Pharmacology (medical) Basal cell carcinoma education Melanoma Aged Retrospective Studies Aged 80 and over Transplantation education.field_of_study integumentary system business.industry Incidence Incidence (epidemiology) Middle Aged medicine.disease United States Carcinoma Basal Cell Carcinoma Squamous Cell Heart Transplantation Female Skin cancer business |
| Zdroj: | American Journal of Transplantation. 11:1488-1497 |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/j.1600-6143.2011.03598.x |
| Popis: | Skin cancer incidence has been shown to be increased in the context of transplant-associated immunosuppression. There is, however, limited information specifically about the incidence of skin cancer after cardiac transplantation in the United States. A 10-year retrospective cohort study of 6271 heart transplants at 32 US transplant centers revealed increased postprocedure incidence of nonmelanoma and melanoma skin cancers, especially cutaneous squamous cell carcinoma, for which the incidence increased from 4- to 30-fold compared to the age and gender equivalent general population. Incidence of skin cancer in this study was consistent with prior single-center data regarding cardiac transplant patients. Comparison of all-cause mortality statistics for patients with basal cell carcinoma, squamous cell carcinoma and melanoma, respectively, demonstrated increased mortality associated with melanoma. Skin cancer screening and prophylaxis may be of some utility in reducing morbidity and mortality in cardiac transplant patients. |
| Databáze: | OpenAIRE |
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