Correction to: Abnormal Cerebellar Volume in Patients with Remitted Major Depression with Persistent Cognitive Deficits
| Autor: | Daniela Roesch-Ely, Katharina M. Kubera, R. Christian Wolf, Claudia Bach, Malte S. Depping, Mike M. Schmitgen, Johanna Kienzle, Lena Listunova |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Neurology MEDLINE Text mining Cerebellum medicine Humans In patient Cognitive Dysfunction Depression (differential diagnoses) Depressive Disorder Major Cognitive Behavioral Therapy business.industry Correction Cognition Organ Size Middle Aged Magnetic Resonance Imaging Female Neurology (clinical) business Volume (compression) |
| Zdroj: | Cerebellum (London, England) |
| ISSN: | 1473-4230 1473-4222 |
| Popis: | Cerebellar involvement in major depressive disorder (MDD) has been demonstrated by a growing number of studies, but it is unknown whether cognitive functioning in depressed individuals is related to cerebellar gray matter volume (GMV) abnormalities. Impaired attention and executive dysfunction are characteristic cognitive deficits in MDD, and critically, they often persist despite remission of mood symptoms. In this study, we investigated cerebellar GMV in patients with remitted MDD (rMDD) that showed persistent cognitive impairment. We applied cerebellum-optimized voxel-based morphometry in 37 patients with rMDD and with cognitive deficits, in 12 patients with rMDD and without cognitive deficits, and in 36 healthy controls (HC). Compared with HC, rMDD patients with cognitive deficits had lower GMV in left area VIIA, crus II, and in vermal area VIIB. In patients with rMDD, regression analyses demonstrated significant associations between GMV reductions in both regions and impaired attention and executive dysfunction. Compared with HC, patients without cognitive deficits showed increased GMV in bilateral area VIIIB. This study supports cerebellar contributions to the cognitive dimension of MDD. The data also point towards cerebellar area VII as a potential target for non-invasive brain stimulation to treat cognitive deficits related to MDD. |
| Databáze: | OpenAIRE |
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