Effects of 6% Tetrastarch and Lactated Ringer's Solution on Extravascular Lung Water and Markers of Acute Renal Injury in Hemorrhaged, Isoflurane-Anesthetized Healthy Dogs

Autor: M. S. Diniz, B López-Castañeda, Mariana Werneck Fonseca, Francisco J. Teixeira-Neto, Carolina Hagy Girotto, A C Oliveira-Garcia, Nathalia Celeita-Rodríguez
Přispěvatelé: Universidade Estadual Paulista (Unesp)
Rok vydání: 2017
Předmět:
Male
Cardiac output
Hydroxyethyl starch
Plasma Substitutes
Standard Article
0403 veterinary science
Hydroxyethyl Starch Derivatives
chemistry.chemical_compound
0302 clinical medicine
030202 anesthesiology
Medicine
Nephrology/Urology
Prospective Studies
Crystalloids
Cardiac Output
Neutrophil gelatinase-associated lipocalin
lcsh:Veterinary medicine
Cross-Over Studies
Isoflurane
Acute kidney injury
04 agricultural and veterinary sciences
Standard Articles
Anesthesia
Creatinine
Anesthetics
Inhalation
Ringer's solution
Female
medicine.drug
Ringer's Lactate
040301 veterinary sciences
Hemorrhage
Sepsis
03 medical and health sciences
Dogs
Lipocalin-2
Animals
Colloids
General Veterinary
business.industry
Neutrophil gelatinase‐associated lipocalin
Oxygenation
medicine.disease
chemistry
Extravascular Lung Water
lcsh:SF600-1100
SMALL ANIMAL
Isotonic Solutions
business
Zdroj: Journal of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine, Vol 32, Iss 2, Pp 712-721 (2018)
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 1939-1676
Popis: Made available in DSpace on 2018-11-26T15:47:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-03-01 Fundacao de Amparo a Pesquisa de Sao Paulo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) BackgroundTetrastarch can cause acute kidney injury (AKI) in humans with sepsis, but less likely to result in tissue edema than lactated Ringer's solution (LRS). ObjectivesCompare effects of volume replacement (VR) with LRS and 6% tetrastarch solution (TS) on extravascular lung water (EVLW) and markers of AKI in hemorrhaged dogs. AnimalsSix healthy English Pointer dogs (19.7-35.3 kg). MethodsProspective crossover study. Animals underwent anesthesia without hemorrhage (Control). Two weeks later, dogs hemorrhaged under anesthesia on 2 occasions (8-week washout intervals) and randomly received VR with LRS or TS at 3 : 1 or 1 : 1 of shed blood, respectively. Anesthesia was maintained until 4 hour after VR for EVLW measurements derived from transpulmonary thermodilution cardiac output. Neutrophil gelatinase-associated lipocalin (NGAL) and creatinine concentrations in plasma and urine were measured until 72 hour after VR. ResultsThe EVLW index (mL/kg) was lower at 1 hour after TS (10.0 1.9) in comparison with controls (11.9 +/- 3.4, P = 0.04), and at 4 hour after TS (9.7 +/- 1.9) in comparison with LRS (11.8 +/- 2.7, P = 0.03). Arterial oxygen partial pressure-to-inspired oxygen fraction ratio did not differ among treatments from 0.5 to 4 hour after VR. Urine NGAL/creatinine ratio did not differ among treatments and remained below threshold for AKI (120,000 pg/mg). Conclusions and Clinical ImportanceAlthough TS causes less EVLW accumulation than LRS, neither fluid produced evidence of lung edema (impaired oxygenation). Both fluids appear not to cause AKI when used for VR after hemorrhage in healthy nonseptic dogs. Univ Estadual Paulista, Fac Med, Botucatu, SP, Brazil Univ Estadual Paulista, Fac Med Vet & Zootecnia, BR-18618970 Botucatu, SP, Brazil Univ Estadual Paulista, Fac Med, Botucatu, SP, Brazil Univ Estadual Paulista, Fac Med Vet & Zootecnia, BR-18618970 Botucatu, SP, Brazil Fundacao de Amparo a Pesquisa de Sao Paulo: 2014/25115-8 Fundacao de Amparo a Pesquisa de Sao Paulo: 2015/04810-2 Fundacao de Amparo a Pesquisa de Sao Paulo: 2017/19711-5 CNPq: 306342/2015-4
Databáze: OpenAIRE
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