Agranulocytosis following infectious mononucleosis
| Autor: | Mitsufumi Mayumi, Takeshi Miyanomae, T. Hamamoto, S. Sumimoto, Haruki Mikawa, Yoshitaka Iwai, Y. Kasajima |
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| Rok vydání: | 1990 |
| Předmět: |
Macrophage colony-stimulating factor
Myeloid Mononucleosis CFU-GM Granulocyte Colony-Stimulating Factors Bone Marrow medicine Humans Infectious Mononucleosis Colony-forming unit biology business.industry Macrophages medicine.disease medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Immunology biology.protein Female Bone marrow Antibody business Agranulocytosis Granulocytes |
| Zdroj: | European journal of pediatrics. 149(10) |
| ISSN: | 0340-6199 |
| Popis: | A girl developed acute agranulocytosis (45/mm3), 37 days after the onset of infectious mononucleosis. The bone marrow showed myeloid hyperplasia with maturation arrest and erythroid hypoplasia. A normal amount of colony forming units of granulocytes and macrophages (CFU-GM) colonies with a relative high number of clusters was observed. Neither anti-neutrophil antibodies nor circulating inhibitors of colony growth were found in serum. Granulocyte and macrophage colony stimulating factor (GM-CSF) activity in the patient's serum rose at this time. The agranulocytosis lasted 5 days and her clinical state soon improved. These results suggested that agranulocytosis was presumably not due to serum factors, including auto-antibodies and/or suppressive substances, and that Epstein-Barr virus (EBV) had some direct or indirect effect on the marrow cells of the myeloid series. |
| Databáze: | OpenAIRE |
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