Identification of Viral Macrophage Inflammatory Protein (vMIP)-II as a Ligand for GPR5/XCR1
| Autor: | Joseph A. Hedrick, Daniel Lundell, Albert Zlotnik, Elizabeth Oldham, Heather Kaminski, Eric L. Gustafson, Daniel Catron, LiXin Shan, Xudong Qiao |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
CCR1
Sialoglycoproteins Biophysics Gene Expression Receptors Cell Surface C-C chemokine receptor type 6 Ligands CCL7 Biochemistry Cell Line Receptors G-Protein-Coupled Mice Viral Proteins Chemokine receptor Animals Humans Tissue Distribution Cloning Molecular CCL13 CX3CL1 Molecular Biology DNA Primers Lymphokines Base Sequence Chemistry Membrane Proteins Cell Biology Macrophage Inflammatory Proteins Recombinant Proteins Chemokines C Cell biology Immunology XCL2 Calcium Chemokines CCL21 |
| Zdroj: | Biochemical and Biophysical Research Communications. 268:938-941 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.2000.2235 |
| Popis: | Lymphotactin is unique among chemokines in that it contains only two of four conserved cysteines and may possess a structure less constrained than other chemokines. The viral chemokine vMIP-II, which presumably has a structure similar to that of CC chemokines has been shown to inhibit many chemokine receptors, but its activity at GPR5/XCR1 has not been described. Interestingly, vMIP-II (but not vMIP-I) was found to be a potent antagonist of lymphotactin activity at GPR5/XCR1, extending the range of chemokine classes that this viral protein is known to inhibit to include the C class chemokine. In addition, we have extended previous analyses of GPR5/XCR1 expression and show that this receptor is expressed in leukocyte cells previously shown to be responsive to lymphotactin. |
| Databáze: | OpenAIRE |
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