GCY-35/GCY-36—TAX-2/TAX-4 Signalling in O2 Sensory Neurons Mediates Acute Functional Ethanol Tolerance in Caenorhabditis elegans
| Autor: | Zheng-Xing Wu, Chang Li Ge, Ming Hai Ge, Hong Wang, Yu Zhang, Yuan Hua Chen, Qing Qin He, Wei Tian |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Sensory Receptor Cells lcsh:Medicine Sensory system Article Ion Channels 03 medical and health sciences chemistry.chemical_compound medicine Animals Ethanol metabolism Receptor lcsh:Science Caenorhabditis elegans Caenorhabditis elegans Proteins Cyclic GMP Sensitization Multidisciplinary Ethanol biology lcsh:R Drug Tolerance biology.organism_classification Hedgehog signaling pathway Guanylate Cyclase-Activating Proteins Receptors Neuropeptide Y Oxygen 030104 developmental biology medicine.anatomical_structure Signalling chemistry Guanylate Cyclase lcsh:Q Neuroscience Signal Transduction |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Ethanol is a widely used beverage and abused drug. Alcoholism causes severe damage to human health and creates serious social problems. Understanding the mechanisms underlying ethanol actions is important for the development of effective therapies. Alcohol has a wide spectrum of effects on physiological activities and behaviours, from sensitization to sedation and even intoxication with increasing concentrations. Animals develop tolerance to ethanol. However, the underlying mechanisms are not well understood. In Caenorhabditis elegans, NPR-1 negatively regulates the development of acute tolerance to ethanol. Here, using in vivo Ca2+ imaging, behavioural tests and chemogenetic manipulation, we show that the soluble guanylate cyclase complex GCY-35/GCY-36—TAX-2/TAX-4 signalling pathway in O2 sensory neurons positively regulates acute functional tolerance in npr-1 worms. |
| Databáze: | OpenAIRE |
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