Preclinical Evaluation of Polymeric Nanocomposite Containing Pregabalin for Sustained Release as Potential Therapy for Neuropathic Pain

Autor:	Thamyris Reis Moraes, Gislaine Ribeiro Pereira, Rafaela Figueiredo Rodrigues, Paloma Freitas dos Santos, Rodrigo Vicentino Placido, Flávia Chiva Carvalho, Sandra Barbosa Neder Agostini, Vanessa Bergamin Boralli, Giovane Galdino, Jennifer Tavares Jacon Freitas, Juliana Cancino-Bernardi, Juliana Barbosa Nunes
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	preclinical investigation Polymers and Plastics medicine.drug_class Sleep induction Chemistry Pregabalin Organic chemistry General Chemistry Pharmacology induced sleep Article TOXICOLOGIA QD241-441 Nociception polymeric nanoparticles Pharmacokinetics pharmacokinetics of pregabalin Barbiturate Neuropathic pain Drug delivery medicine Distribution (pharmacology) neuropathy antinociceptive effect medicine.drug
Zdroj:	Polymers Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Polymers, Vol 13, Iss 3837, p 3837 (2021) Volume 13 Issue 21
ISSN:	2073-4360
Popis:	This study offers a novel oral pregabalin (PG)-loaded drug delivery system based on chitosan and hypromellose phthalate-based polymeric nanocomposite in order to treat neuropathic pain (PG-PN). PG-PN has a particle size of 432 ± 20 nm, a polydispersity index of 0.238 ± 0.001, a zeta potential of +19.0 ± 0.9 mV, a pH of 5.7 ± 0.06, and a spherical shape. Thermal and infrared spectroscopy confirmed nanocomposite generation. PG-PN pharmacokinetics was studied after a single oral dose in male Wistar rats. PG-PN showed greater distribution and clearance than free PG. The antinociceptive effect of PG-PN in neuropathic pain rats was tested by using the chronic constriction injury model. The parameter investigated was the mechanical nociceptive threshold measured by the von Frey filaments test PG-PN showed a longer antinociceptive effect than free PG. The rota-rod and barbiturate sleep induction procedures were used to determine adverse effects the criteria included motor deficit and sedative effects. PG-PN and free PG had plenty of motors. PG-PN exhibited a less sedative effect than free PG. By prolonging the antinociceptive effect and decreasing the unfavorable effects, polymeric nanocomposites with pregabalin have shown promise in treating neuropathic pain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87f2ce914fbc14d6150c7224439afe6 http://europepmc.org/articles/PMC8587775 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.