Efficacy of the Canine Influenza Virus H3N8 Vaccine To Decrease Severity of Clinical Disease after Cochallenge with Canine Influenza Virus and Streptococcus equi subsp. zooepidemicus
| Autor: | Huchappa Jayappa, Ronald D. Schultz, Bliss Thiel, Tamara Davis, Nallakannu Lakshmanan, Jamie Henningson, Muralidhar S. Deshpande, Patricia Sharp, Terri Lee Wasmoen, Laurie J. Larson |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Microbiology (medical) Streptococcus equi Influenza vaccine Canine influenza Clinical Biochemistry Immunology Population Biology medicine.disease_cause Veterinary Immunology Microbiology Influenza A Virus H3N8 Subtype Dogs Orthomyxoviridae Infections Streptococcal Infections Influenza A virus medicine Animals Immunology and Allergy Dog Diseases education education.field_of_study medicine.disease Virology United States Streptococcus equi subsp. zooepidemicus Influenza Vaccines Inactivated vaccine Coinfection Female Post-Exposure Prophylaxis |
| Zdroj: | Clinical and Vaccine Immunology |
| ISSN: | 1556-679X 1556-6811 |
| DOI: | 10.1128/cvi.00500-10 |
| Popis: | Since first emerging in the North American canine population in 2004, canine influenza virus (CIV) subtype H3N8 has shown horizontal transmission among dogs, with a high level of adaptation to this species. The severity of disease is variable, and coinfection by other respiratory pathogens is an important factor in the degree of morbidity and mortality. The first influenza vaccine for dogs, an inactivated vaccine containing CIV subtype H3N8, was conditionally approved by the U.S. Department of Agriculture (USDA) for licensure in May 2009 and fully licensed in June 2010. This study evaluates the efficacy of this vaccine to reduce the severity of illness in dogs cochallenged with virulent CIV andStreptococcus equisubsp.zooepidemicus. |
| Databáze: | OpenAIRE |
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