UV Radiation and the Skin
| Autor: | Timothy L. Scott, John A. D'Orazio, Alexandra Amaro-Ortiz, Stuart G. Jarrett |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Pathology
Skin Neoplasms Skin Pigmentation Review medicine.disease_cause Melanin lcsh:Chemistry melanocortin 1 receptor 0302 clinical medicine pigmentation lcsh:QH301-705.5 Spectroscopy 0303 health sciences integumentary system Melanoma General Medicine 3. Good health Computer Science Applications melanin 030220 oncology & carcinogenesis carcinogenesis mutagenesis Ultraviolet radiation medicine.medical_specialty skin Ultraviolet Rays Biology Catalysis Inorganic Chemistry 03 medical and health sciences medicine Animals Humans cancer Basal cell carcinoma Physical and Theoretical Chemistry Molecular Biology Carcinogen 030304 developmental biology Melanins Organic Chemistry Cancer medicine.disease Oxidative Stress lcsh:Biology (General) lcsh:QD1-999 Cancer research Skin cancer Carcinogenesis Melanocortin 1 receptor |
| Zdroj: | International Journal of Molecular Sciences, Vol 14, Iss 6, Pp 12222-12248 (2013) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | UV radiation (UV) is classified as a "complete carcinogen" because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter. In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other environmentally-influenced skin disorders. However, UV also benefits human health by mediating natural synthesis of vitamin D and endorphins in the skin, therefore UV has complex and mixed effects on human health. Nonetheless, excessive exposure to UV carries profound health risks, including atrophy, pigmentary changes, wrinkling and malignancy. UV is epidemiologically and molecularly linked to the three most common types of skin cancer, basal cell carcinoma, squamous cell carcinoma and malignant melanoma, which together affect more than a million Americans annually. Genetic factors also influence risk of UV-mediated skin disease. Polymorphisms of the melanocortin 1 receptor (MC1R) gene, in particular, correlate with fairness of skin, UV sensitivity, and enhanced cancer risk. We are interested in developing UV-protective approaches based on a detailed understanding of molecular events that occur after UV exposure, focusing particularly on epidermal melanization and the role of the MC1R in genome maintenance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|