Epidemiological and genetic characteristics of norovirus outbreaks in long-term care facilities, 2003-2006
| Autor: | N. A. Rosenthal, L. E. Lee, William E. Keene, Jan Vinjé, Katrina Hedberg, Paul R Cieslak, B. A. J. Vermeulen, Marc-Alain Widdowson |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Veterinary medicine biology Genotype Epidemiology Attack rate Norovirus Outbreak biology.organism_classification medicine.disease_cause Virology Long-Term Care Caliciviridae Residential Facilities Disease Outbreaks Long-term care Infectious Diseases Caliciviridae Infections medicine Humans Seasons |
| Zdroj: | Epidemiology and infection. 139(2) |
| ISSN: | 1469-4409 |
| Popis: | SUMMARYTo identify the epidemiological and genetic characteristics of norovirus (NoV) outbreaks and estimate the impact of NoV infections in an older population, we analysed epidemiological and laboratory data collected using standardized methods from long-term care facilities (LTCFs) during 2003–2006. Faecal specimens were tested for NoV by real-time reverse transcriptase–polymerase chain reaction. NoV strains were genotyped by sequencing. Of the 234 acute gastroenteritis (AGE) outbreaks reported, 163 (70%) were caused by NoV. The annual attack rate of outbreak-associated NoV infection in LTCF residents was 4%, with a case-hospitalization rate of 3·1% and a case-fatality rate of 0·5%. GII.4 strains accounted for 84% of NoV outbreaks. Median duration of illness was longer for GII.4 infections than non-GII.4 infections (33 vs. 24 h, P |
| Databáze: | OpenAIRE |
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