A Ketogenic Diet Favorably Affects Serum Biomarkers for Cardiovascular Disease in Normal-Weight Men
| Autor: | N G. Avery, Ana L. Gómez, Jeff S. Volek, Timothy P. Scheett, D M. Love, Matthew J. Sharman, William J. Kraemer |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) Blood lipids chemistry.chemical_compound Reference Values Weight loss Internal medicine medicine Humans Insulin Triglycerides Nutrition and Dietetics Triglyceride business.industry Cholesterol Body Weight Fasting Ketosis Middle Aged Postprandial Period medicine.disease Dietary Fats Lipids Diet Lipoproteins LDL Endocrinology Postprandial chemistry Cardiovascular Diseases lipids (amino acids peptides and proteins) medicine.symptom Energy Intake business Biomarkers Ketogenic diet |
| Zdroj: | The Journal of Nutrition. 132:1879-1885 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/132.7.1879 |
| Popis: | Very low-carbohydrate (ketogenic) diets are popular yet little is known regarding the effects on serum biomarkers for cardiovascular disease (CVD). This study examined the effects of a 6-wk ketogenic diet on fasting and postprandial serum biomarkers in 20 normal-weight, normolipidemic men. Twelve men switched from their habitual diet (17% protein, 47% carbohydrate and 32% fat) to a ketogenic diet (30% protein, 8% carbohydrate and 61% fat) and eight control subjects consumed their habitual diet for 6 wk. Fasting blood lipids, insulin, LDL particle size, oxidized LDL and postprandial triacylglycerol (TAG) and insulin responses to a fat-rich meal were determined before and after treatment. There were significant decreases in fasting serum TAG (-33%), postprandial lipemia after a fat-rich meal (-29%), and fasting serum insulin concentrations (-34%) after men consumed the ketogenic diet. Fasting serum total and LDL cholesterol and oxidized LDL were unaffected and HDL cholesterol tended to increase with the ketogenic diet (+11.5%; P = 0.066). In subjects with a predominance of small LDL particles pattern B, there were significant increases in mean and peak LDL particle diameter and the percentage of LDL-1 after the ketogenic diet. There were no significant changes in blood lipids in the control group. To our knowledge this is the first study to document the effects of a ketogenic diet on fasting and postprandial CVD biomarkers independent of weight loss. The results suggest that a short-term ketogenic diet does not have a deleterious effect on CVD risk profile and may improve the lipid disorders characteristic of atherogenic dyslipidemia. |
| Databáze: | OpenAIRE |
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