Aryl hydrocarbon hydroxylase activity in chemically induced and toremifene-treated mammary tumors in rats
| Autor: | Matti Lähde, Ulla-Marjut Jaakkola, Sari Ala-Uotila, Kaija Pyykkö |
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| Rok vydání: | 2007 |
| Předmět: |
Cancer Research
medicine.medical_specialty 9 10-Dimethyl-1 2-benzanthracene Mammary gland Uterus Reductase Malignant transformation Rats Sprague-Dawley Mammary Glands Animal Internal medicine medicine Animals Toremifene Lung NADPH-Ferrihemoprotein Reductase Unspecific monooxygenase biology Mammary Neoplasms Experimental Cytochrome P450 Rats medicine.anatomical_structure Endocrinology Liver Oncology biology.protein Microsome Female Aryl Hydrocarbon Hydroxylases Drug Screening Assays Antitumor medicine.drug |
| Zdroj: | International Journal of Cancer. 56:140-145 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.2910560125 |
| Popis: | Aryl hydrocarbon hydroxylase (AHH) and NADPH-cyto-chrome P450 reductase (NCR) activity of microsomes from liver, lungs, uterus and mammary tumors in dimethylbenz-antrachene-induced and torem'rfene-treated female Sprague-Dawley rats were studied. AHH and NCR activity in tumors and uteri was low compared with that in livers and lungs. The distribution of AHH in tumors was wide and skewed. It varied in different tumors of the same animal as widely as between different animals. The enzyme activity in tumors did not correlate with that in the liver, lungs or uterus of the same animal. Toremifene had no effect on AHH or NCR in tumor or liver, but it decreased them in lungs. Tumor AHH activity correlated with its overall growth rate and development stage. The results suggest that malignant transformation leading to the defect in growth regulation also confuses the complex regulatory system of AHH activity. |
| Databáze: | OpenAIRE |
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