Interaction of antioxidants and exercise on insulin sensitivity in healthy and prediabetic rats
| Autor: | W. Wayne Lautt, Dallas J. Legare, Kawshik K. Chowdhury |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Physiology medicine.medical_treatment Antioxidants Body Mass Index Prediabetic State Rats Sprague-Dawley Random Allocation Physiology (medical) Internal medicine Physical Conditioning Animal medicine Animals Insulin Radionuclide Imaging Sensitization Adiposity Pharmacology business.industry Insulin sensitivity General Medicine Postprandial Period Glutathione Rats medicine.anatomical_structure Endocrinology Postprandial Glucose Liver Insulin Resistance business |
| Zdroj: | Canadian journal of physiology and pharmacology. 91(7) |
| ISSN: | 1205-7541 |
| Popis: | Meal-induced insulin sensitization (MIS) describes the augmented postprandial response to insulin through action of the hepatic insulin sensitizing substance (HISS). HISS-action is impaired in insulin resistance associated with aging and type 2 diabetes, but could be preserved by the antioxidant cocktail SAMEC, along with voluntary exercise. In this study, we tested whether antioxidant supplementation during voluntary training would interact with the effects of exercise on HISS-mediated glucose uptake in healthy and prediabetic rats. The 7-day voluntary running-wheel training was used as an exercise intervention. SAMEC supplementation was provided only during the 7-day training session. The rapid insulin sensitivity test (RIST) was conducted to determine insulin- and HISS-dependent glucose uptake in 14-week-old healthy rats, and sucrose-induced insulin-resistant rats, with or without exercise in the presence or absence of SAMEC supplementation. The postprandial insulin sensitivity was increased by exercise, primarily through enhancement of the HISS-dependent glucose uptake, which remained unaffected by SAMEC. SAMEC supplementation did not either harm or add benefit to the positive effects of exercise on insulin sensitivity in healthy or prediabetic rats. While SAMEC alone was a demonstrated preventive against the progressive loss of HISS action in previous studies, short-term supplementation in this study did not reverse the established disease state. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|