Cancer metabolism in space and time: Beyond the Warburg effect
| Autor: | Luigi Ippolito, Debora Grasso, Valéry Payen, Piotr Bański, Pierre Sonveaux, Pierre Danhier, Paolo E. Porporato |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Stromal cell Biophysics Context (language use) Mitochondrion Biology Biochemistry Metastasis 03 medical and health sciences Neoplasms medicine Animals Humans Neoplasm Metastasis Cancer Heterogeneity Metabolism Mitochondria Cell Biology Cell Death medicine.disease Warburg effect 3. Good health Cell biology 030104 developmental biology Tumor progression Cancer cell Cancer research Neoplastic Stem Cells Stromal Cells Energy Metabolism Glycolysis Cell Division Metabolic Networks and Pathways |
| Zdroj: | Biochimica et Biophysica Acta (BBA)-Bioenergetics |
| Popis: | Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing energy, reducing equivalents and building blocks while several metabolites exert a signaling function promoting tumor growth and progression. A cancer tissue cannot be simply reduced to a bulk of proliferating cells. Tumors are indeed complex and dynamic structures where single cells can heterogeneously perform various biological activities with different metabolic requirements. Because tumors are composed of different types of cells with metabolic activities affected by different spatial and temporal contexts, it is important to address metabolism taking into account cellular and biological heterogeneity. In this review, we describe this heterogeneity also in metabolic fluxes, thus showing the relative contribution of different metabolic activities to tumor progression according to the cellular context. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux. |
| Databáze: | OpenAIRE |
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