Effects of aging on bone mineral content and bone biomarkers in female cynomolgus monkeys
| Autor: | Katsuhiko Sato, Masaru Shimizu, Takashi Yoshida, Yasuhiro Yoshikawa, Kunihiko Tsunemi, Masao Koto, Yang Chen |
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| Rok vydání: | 2000 |
| Předmět: |
Peak bone mass
medicine.medical_specialty Aging Bone density Osteocalcin General Biochemistry Genetics and Molecular Biology Bone resorption Collagen Type I Bone Density Internal medicine medicine Animals Lumbar Vertebrae General Veterinary biology business.industry Body Weight Acid phosphatase General Medicine Alkaline Phosphatase Skeleton (computer programming) Peptide Fragments Radiography Macaca fascicularis Endocrinology biology.protein Alkaline phosphatase Animal Science and Zoology Female Collagen business Densitometry Peptides Biomarkers Procollagen |
| Zdroj: | Experimental animals. 49(3) |
| ISSN: | 1341-1357 |
| Popis: | Age-related changes in bone mineral content and bone biomarkers were assessed over the complete lifespan of female cynomolgus monkeys. The bone mass of the lumbar spine increased linearly from birth to about 2.5 years of age, and this increase gradually slowed thereafter until a peak bone mass was achieved at 9 years of age. The bone mass stabilized after 9 years of age, showing no sign of further reduction with age. In contrast with the significant increase in bone mass before 2.5 years of age, significant decreases occurred in the serum concentrations of the following bone formation markers: intact osteocalcin, bone-specific alkaline phosphatase and amino-terminal propeptide of type I procollagen, but the serum concentration of carboxy-terminal propeptide of type I procollagen did not change significantly throughout the entire lifespan. Concerning the bone resorption markers, the levels of tartrate-resistant acid phosphatase fluctuated throughout the entire lifespan. The skeleton of an aging female monkey undergoes changes similar to those observed in senescent humans, but did not undergo the menopausal changes seen in women. The use of female cynomolgus monkeys to model human skeletal interventions should therefore be undertaken with consideration of the similarities and differences between cynomolgus monkeys and humans. |
| Databáze: | OpenAIRE |
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