HIV-1 infection among malnourished children in Butare, Rwanda
| Autor: | Thomas Rehle, Théophile Gatsinzi, Jean-Baptiste Kurawige, Vera Kleinfeldt, Marc Bulterys |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Pediatric AIDS Population Mothers Protein-Energy Malnutrition Acquired immunodeficiency syndrome (AIDS) Weight for Age Epidemiology HIV Seropositivity Medicine Humans education Child education.field_of_study business.industry Rwanda Infant medicine.disease Child mortality Malnutrition Infectious Diseases El Niño Child Preschool Pediatrics Perinatology and Child Health Immunology Female business Follow-Up Studies |
| Zdroj: | Journal of tropical pediatrics. 39(2) |
| ISSN: | 0142-6338 |
| Popis: | In order to investigate the relationship between human immunodeficiency virus (HIV-1) infection and protein-energy malnutrition (PEM), all 101 malnourished children who were admitted to the Department of Pediatrics of the National University Hospital between February and July of 1989 (median age = 2.5 years), and who were accompanied by their mother were screened for HIV-1 antibody. Mothers were also screened and interviewed. Mother-child pairs were followed-up 2 years later to determine mortality and clinical status. Fourteen per cent of malnourished children were HIV-1 seropositive. Only one seropositive child had a seronegative mother. This child had a history of multiple blood transfusions and injections. Among children above 15 months of age, HIV-1 seropositivity was more common among marasmic children than among malnourished children presenting with oedema at admission to the hospital. Also, HIV-1 infection was found more frequently among chronically malnourished children (low height for age and weight for age) than among acutely malnourished children (low weight for height). Mortality during the 2-year follow-up was 75 per cent among HIV-1 seropositive children and 23 per cent among HIV-1 seronegatives (mortality density ratio = 6.2; 95 per cent confidence interval = 2.2-17.4). Severe, chronic PEM should always alert health workers to the possible diagnosis of pediatric AIDS, and its implications for treatment and prognosis. |
| Databáze: | OpenAIRE |
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