Epidemiology of Infectious Complications During Extracorporeal Membrane Oxygenation in Children

Autor: Roberto Bandettini, Elisabetta Lampugnani, Livia Gargiullo, Stefano Pezzato, Paola Tatarelli, Ilaria Caviglia, Chiara Grasso, Anna Loy, Elio Castagnola, Pietro Tuo, Andrea Moscatelli
Rok vydání: 2018
Předmět:
Adult
Male
Microbiology (medical)
medicine.medical_specialty
Adolescent
Staphylococcus
medicine.medical_treatment
Bacteremia
030204 cardiovascular system & hematology
Intensive Care Units
Pediatric
Artificial respiration
Tertiary Care Centers
Young Adult
03 medical and health sciences
Extracorporeal Membrane Oxygenation
0302 clinical medicine
Risk Factors
Epidemiology
Prevalence
medicine
Extracorporeal membrane oxygenation
Humans
Pseudomonas Infections
030212 general & internal medicine
Child
Retrospective Studies
Pediatric intensive care unit
business.industry
Infant
Newborn
Bacterial pneumonia
Infant
Retrospective cohort study
Pneumonia
Staphylococcal Infections
medicine.disease
surgical procedures
operative
Infectious Diseases
Italy
Child
Preschool
Pseudomonas aeruginosa
Pediatrics
Perinatology and Child Health
Emergency medicine
Female
business
Zdroj: Pediatric Infectious Disease Journal. 37:624-626
ISSN: 0891-3668
DOI: 10.1097/inf.0000000000001873
Popis: Background Infections represent a severe complication of extracorporeal membrane oxygenation (ECMO). Aim of the present study was to describe the epidemiology of infections acquired during ECMO in a tertiary care children's hospital. Methods Retrospective analysis of clinical records of patients undergoing ECMO between January 2009 and December 2016. For each patient, data were collected on clinical characteristics, modality of ECMO support, site and etiology of documented infections, survival within 1 week after ECMO weaning and/or at pediatric intensive care unit discharge. These data were employed to evaluate overall infection prevalence, infection rate expressed as episodes/1000 days of support and cumulative risk estimates of infections occurring during ECMO. Results During the study period, a total of 46 ECMO procedures were performed. The overall prevalence of documented infections was 33%, with an infection rate of 27.22 and a cumulative risk of 55%. Bloodstream infection represented the most frequently documented (53%), followed by pneumonia (40%). Coagulase-negative staphylococci and Pseudomonas aeruginosa prevailed as isolated pathogens. Overall survival was 59%, and 46% among those developing infections during ECMO. Conclusions ECMO is a procedure at high risk for infections. Our data, limited to 1 center, represent a recent benchmark for further investigations.
Databáze: OpenAIRE
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