Effect of 20% in vitro haemodilution with warmed buffered salt solution and cerebrospinal fluid on coagulation
| Autor: | T. G. Ruttmann, Michael F. M. James, K. F. Wells |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Body fluid
Hemodilution medicine.diagnostic_test business.industry Plasma Substitutes Balanced salt solution Thromboelastography Thrombelastography Anesthesiology and Pain Medicine Cerebrospinal fluid Degree Celsius Anesthesia Coagulation testing medicine Humans business Blood Coagulation Cerebrospinal Fluid Blood coagulation test Whole blood |
| Zdroj: | British Journal of Anaesthesia. 82:110-111 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/82.1.110 |
| Popis: | We have conducted an in vitro coagulation study consisting of two separate groups of 20 subjects using the thrombelastograph. In the first group, haemodilution was performed with a physiological balanced salt solution similar to plasma, with the exception of calcium, and buffered to a normal pH (Plasmalyte B) at 37 degrees C on blood obtained from consenting volunteers. In the second group, a protein-poor body fluid (cerebrospinal fluid (CSF)) obtained from parturient patients undergoing spinal anaesthesia for Caesarean section was used as the diluent. There were statistically significant differences between the warmed Plasmalyte B treated samples and their untreated controls for all variables measured by the thrombelastograph, except for maximum amplitude, and between the CSF treated samples and their untreated controls for all variables. We conclude that electrolyte and acid-base composition of the diluent fluid had no effect on the observation that crystalloid haemodilution produces hypercoagulability. The marked increase in coagulability produced by addition of CSF cannot be explained on a simple haemodilution basis and confirms previous suggestions of the presence of a procoagulant factor in CSF. |
| Databáze: | OpenAIRE |
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