Application of the draft NIOSH Occupational Exposure Banding Process to Bisphenol A: A case study
| Autor: | Christine Whittaker, Lauralynn T. McKernan, Pranav Rane, Cynthia J. Hines, Thomas J. Lentz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
endocrine system
Bisphenol A Materials science Air Pollutants Occupational 010501 environmental sciences Risk Assessment 01 natural sciences Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Phenols Polycarbonate plastic Occupational Exposure Benzhydryl Compounds Hazard evaluation Occupational Health 0105 earth and related environmental sciences Public Health Environmental and Occupational Health Epoxy Pulp and paper industry 030210 environmental & occupational health Chemical used United States chemistry visual_art visual_art.visual_art_medium Occupational exposure National Institute for Occupational Safety and Health U.S |
| Zdroj: | J Occup Environ Hyg |
| DOI: | 10.6084/m9.figshare.7667993.v1 |
| Popis: | Bisphenol A is a commercially important chemical used to make polycarbonate plastic, epoxy resins, and other specialty products. Despite an extensive body of in vitro, animal and human observational studies on the effects of exposure to bisphenol A, no authoritative bodies in the U.S. have adopted or recommended occupational exposure limits for bisphenol A. In 2017, the National Institute for Occupational Safety and Health published a Draft process for assigning health-protective occupational exposure bands, i.e., an airborne concentration range, to chemicals lacking an occupational exposure limit. Occupational exposure banding is a systematic process that uses both quantitative and qualitative toxicity information on selected health effect endpoints to assign an occupational exposure band for a chemical. The Draft process proposes three methodological tiers of increasing complexity for assigning an occupational exposure band. We applied Tier 1 (based on the Globally Harmonized System of Classification and Labelling) and Tier 2 (based on authoritative sources/reviews) to assign an occupational exposure band to bisphenol A. Under both Tier 1 and 2, the occupational exposure band for bisphenol A was “E” (3), an assignment based on eye damage. “E” is the lowest exposure concentration range, reserved for chemicals with high potential toxicity. If eye damage was excluded in assigning an air concentration exposure range, then bisphenol A would band as “D” (>0.01 to 0.1 mg/m3) under Tier 1 (based on reproductive toxicity and respiratory/skin sensitization) and under Tier 2 (based on specific target organ toxicity-repeated exposure). In summary, Tiers 1 and 2 gave the same occupational exposure band for bisphenol A when eye damage was included (“E”) or excluded (“D”) as an endpoint. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|