Frontal-striatum dysfunction during reward processing: Relationships to amotivation in schizophrenia
| Autor: | M Deanna, Yu Sun Chung |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Context (language use) Schizoaffective disorder Striatum behavioral disciplines and activities Article 03 medical and health sciences 0302 clinical medicine Reward Neural Pathways mental disorders medicine Humans Prefrontal cortex Biological Psychiatry Motivation medicine.diagnostic_test Anhedonia Middle Aged medicine.disease Magnetic Resonance Imaging Corpus Striatum Frontal Lobe 030227 psychiatry Dorsolateral prefrontal cortex Clinical Psychology Psychiatry and Mental health medicine.anatomical_structure nervous system Schizophrenia Female Schizophrenic Psychology Cues medicine.symptom Psychology Functional magnetic resonance imaging Neuroscience Photic Stimulation psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Journal of Abnormal Psychology. 125:453-469 |
| ISSN: | 1939-1846 0021-843X |
| DOI: | 10.1037/abn0000137 |
| Popis: | Schizophrenia is characterized by deficits of context processing, thought to be related to dorsolateral prefrontal cortex (DLPFC) impairment. Despite emerging evidence suggesting a crucial role of the DLPFC in integrating reward and goal information, we do not know whether individuals with schizophrenia can represent and integrate reward-related context information to modulate cognitive control. To address this question, thirty-six individuals with schizophrenia (n=29) or schizoaffective disorder (n=7) and twenty-seven healthy controls performed a variant of response conflict task (Padmala and Pessoa, 2011) during fMRI scanning, in both baseline and reward conditions, with monetary incentives on some reward trials. We used a mixed state-item design that allowed us to examine both sustained and transient reward effects on cognitive control. Different from predictions about impaired DLPFC function in schizophrenia, we found an intact pattern of increased sustained DLPFC activity during reward vs. baseline blocks in individuals with schizophrenia at a group level but blunted sustained activations in the putamen. Contrary to our predictions, individuals with schizophrenia showed blunted cue-related activations in several regions of the basal ganglia responding to reward-predicting cues. Importantly, as predicted, individual differences in anhedonia/amotivation symptoms severity were significantly associated with reduced sustained DLPFC activation in the same region that showed overall increased activity as a function of reward. These results suggest that individual differences in motivational impairments in schizophrenia may be related to dysfunction of the DLPFC and striatum in motivationally salient situations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|