The investigation of antimicrobial activity of some s-substituted bis-1,2,4-triazole-3-thiones

Autor:	Volodymyr Nahornyi, Anatolii Fotin, Yevhen Karpun, Natalia Nahorna, Denys Demianenko, Tetiana Fotina, Volodymyr Parchenko
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	antimicrobial activity Pharmaceutical Science 1 2 4-Triazole Pharmacy Antimicrobial organic synthesis Combinatorial chemistry RS1-441 chemistry.chemical_compound Pharmacy and materia medica chemistry Pharmacology (medical) 4-triazole
Zdroj:	Pharmacia 68(4): 797-804 Pharmacia, Vol 68, Iss 4, Pp 797-804 (2021)
ISSN:	2603-557X 0428-0296
Popis:	New S-substituted 4-alkyl-5-((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol derivatives have been designed, synthesized and studied their antimicrobial activity on 11 standard Gram-positive and Gram-negative microorganism strains. Their spectral and physicochemical parameters were established using modern comprehensive methods of analysis, including 1H NMR spectroscopy, GC-MS and elemental analysis.It has been found that compound 2a exhibits strong suppression of 5 test strains (MBC = 15.6 µg/mL). Compound 4a showed moderate inhibition of Salmonella pullorum, Escherichia coli O2, Salmonella enteritidis strains (MBC = 31.25 µg/mL) Compound 6a was sensitive toward ten tested bacteria at 31.25 µg/mL concentration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86997db04d2be38e4dd23088d629bf9 https://pharmacia.pensoft.net/article/65761/ Zobrazit plný text záznamu