The investigation of antimicrobial activity of some s-substituted bis-1,2,4-triazole-3-thiones
Autor: | Volodymyr Nahornyi, Anatolii Fotin, Yevhen Karpun, Natalia Nahorna, Denys Demianenko, Tetiana Fotina, Volodymyr Parchenko |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Pharmacia 68(4): 797-804 Pharmacia, Vol 68, Iss 4, Pp 797-804 (2021) |
ISSN: | 2603-557X 0428-0296 |
Popis: | New S-substituted 4-alkyl-5-((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol derivatives have been designed, synthesized and studied their antimicrobial activity on 11 standard Gram-positive and Gram-negative microorganism strains. Their spectral and physicochemical parameters were established using modern comprehensive methods of analysis, including 1H NMR spectroscopy, GC-MS and elemental analysis.It has been found that compound 2a exhibits strong suppression of 5 test strains (MBC = 15.6 µg/mL). Compound 4a showed moderate inhibition of Salmonella pullorum, Escherichia coli O2, Salmonella enteritidis strains (MBC = 31.25 µg/mL) Compound 6a was sensitive toward ten tested bacteria at 31.25 µg/mL concentration. |
Databáze: | OpenAIRE |
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