Diet therapy for inflammatory bowel diseases: The established and the new
| Autor: | Wolfgang Petritsch, F Durchschein, Heinz F. Hammer |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Diet therapy Nutritional Status Disease Gastroenterology Diet Carbohydrate-Restricted 03 medical and health sciences Enteral Nutrition 0302 clinical medicine Crohn Disease Adrenal Cortex Hormones Internal medicine Dietary Carbohydrates Humans Medicine Topic Highlight chemistry.chemical_classification Crohn's disease business.industry Probiotics Remission Induction General Medicine Pouchitis medicine.disease Ulcerative colitis digestive system diseases Gastrointestinal Microbiome Intestines Treatment Outcome 030104 developmental biology Parenteral nutrition chemistry Fermentation Colitis Ulcerative Parenteral Nutrition Total 030211 gastroenterology & hepatology business FODMAP Dysbiosis |
| Zdroj: | World Journal of Gastroenterology. 22:2179-2194 |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v22.i7.2179 |
| Popis: | Although patients with inflammatory bowel diseases (IBD) have a strong interest in dietary modifications as part of their therapeutic management, dietary advice plays only a minor part in published guidelines. The scientific literature shows that dietary factors might influence the risk of developing IBD, that dysbiosis induced by nutrition contributes to the pathogenesis of IBD, and that diet may serve as a symptomatic treatment for irritable bowel syndrome-like symptoms in IBD. The role of nutrition in IBD is underscored by the effect of various dietary therapies. In paediatric patients with Crohn's disease (CD) enteral nutrition (EN) reaches remission rates similar to steroids. In adult patients, however, EN is inferior to corticosteroids. EN is not effective in ulcerative colitis (UC). Total parenteral nutrition in IBD is not superior to steroids or EN. The use of specific probiotics in patients with IBD can be recommended only in special clinical situations. There is no evidence for efficacy of probiotics in CD. By contrast, studies in UC have shown a beneficial effect in selected patients. For patients with pouchitis, antibiotic treatment followed by probiotics, like VSL#3 or Lactobacillus GG, is effective. When probiotics are used, the risk of bacterial translocation and subsequent bacteremia has to be considered. More understanding of the normal intestinal microflora, and better characterization of probiotic strains at the phenotypic and genomic levels is needed as well as clarification of the mechanisms of action in different clinical settings. A FODMAP reduced diet may improve symptoms in IBD. |
| Databáze: | OpenAIRE |
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