Nutritional Targeting of the Microbiome as Potential Therapy for Malnutrition and Chronic Inflammation
| Autor: | Jacob Hamm, Felix Sommer, Sina Kaiser, Lena Schröder, Dora Bordoni, Philip Rosenstiel, Burkhardt Flemer, Finn Hinrichsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
immunometabolism microbiome lcsh:TX341-641 Inflammation Disease nutritional intervention Pathogenesis 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Microbiome Nutrition and Dietetics business.industry Communication Microbiota Probiotics Malnutrition Human physiology Gnotobiotic animal medicine.disease SCFA Diet 030104 developmental biology Immunology Chronic Disease Dysbiosis 030211 gastroenterology & hepatology Nutrition Therapy medicine.symptom business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Nutrients, Vol 12, Iss 3032, p 3032 (2020) |
| ISSN: | 2072-6643 |
| Popis: | Homeostatic interactions with the microbiome are central for a healthy human physiology and nutrition is the main driving force shaping the microbiome. In the past decade, a wealth of preclinical studies mainly using gnotobiotic animal models demonstrated that malnutrition and chronic inflammation stress these homeostatic interactions and various microbial species and their metabolites or metabolic activities have been associated with disease. For example, the dysregulation of the bacterial metabolism of dietary tryptophan promotes an inflammatory environment and susceptibility to pathogenic infection. Clinical studies have now begun to evaluate the therapeutic potential of nutritional and probiotic interventions in malnutrition and chronic inflammation to ameliorate disease symptoms or even prevent pathogenesis. Here, we therefore summarize the recent progress in this field and propose to move further towards the nutritional targeting of the microbiome for malnutrition and chronic inflammation. |
| Databáze: | OpenAIRE |
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