Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO
| Autor: | Shasha Hou, Bing Yang, Jian Tan, Lu He, Yu Zhu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Oncogene Cell Cancer Articles Biology Cell cycle medicine.disease Molecular medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis medicine Cancer research thyroid cancer Gene silencing Alkylglycerone-phosphate synthase biology.gene Thyroid cancer circular RNAs alkylglycerone phosphate synthase |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1074 |
| Popis: | Thyroid cancer is a common primary tumor in China. Therefore, it is important to investigate the underlying molecular mechanism of thyroid cancer in order to achieve effective individualized treatments. In our previous study, a positive correlation between the expression of alkylglycerone phosphate synthase (AGPS) and the malignant phenotype of thyroid cancer cell lines was identified. The inactivation of AGPS was able to decrease the malignancy of cancer, and inhibit tumor growth and invasion. However, the function of AGPS on thyroid cancer was unclear. In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed in order to investigate the underlying molecular mechanism of AGPS for the regulation of thyroid cancer through circRNAs. |
| Databáze: | OpenAIRE |
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